Chao Yang
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Scientific Research
Sexual reproduction relies on the generation of gametes that contain only half of the genetic material of the parental cells; this reduction in chromosome number is achieved through meiosis. Besides its role in maintaining genome size over generations, meiosis generates genetic diversity through a random selection of either the maternal or the paternal homologous chromosome and by an exchange of DNA segments between homologs by meiotic re- combination.
Our group is mainly interested in understanding the molecular regulatory mechanisms of meiosis, especially of the meiotic pairing and recombination, by using Arabidopsis thaliana and Brassica napus as the model organisms.
Unraveling the mystery of meiosis
- Chu L, Zhuang J, Geng M, Zhang Y, Zhu J, Zhang C, Schnittger A, Yi B*, Yang C* ASYNAPSIS3 has diverse dosage-dependent effects on meiotic crossover formation in Brassica napus. The Plant Cell, 2024, koae207, https://doi.org/10.1093/plcell/koae207.
- Pochon G#, Henry IM#, Yang C#, Lory N, Fernández-Jiménez N, Böwer F, Hu B, Carstens L, Tsai HT, Pradillo M, Comai L*, Schnittger A*, The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference, PNAS Nexus, 2023, 2(3): pgac302.
- Yang C*, Sofroni K, Hamamura Y, Hu B, Elbasi HT, Balboni M, Chu L, Stang D, Heese M, Schnittger A* ZYP1-mediated recruitment of PCH2 to the synaptonemal complex remodels the chromosome axis leading to crossover restriction. Nucleic Acids Research, 2022, 50(22): 12924-12937..
- Cheng J, Xu L, Bergér V, Bruckmann A, Yang C, Schubert V, Grasser, KD, Schnittger A, Zheng B, Jiang, H* H3K9 demethylases IBM1 and JMJ27 are required for male meiosis in Arabidopsis thaliana. New Phytologist, 2022, 235(6): 2252-2269..
- Yang C, Sofroni K, Wijnker E, Hamamura Y, Carstens L, Harashima H, Stolze SC, Vezon D, Chelysheva L, Orban-Nemeth Z, Pochon G, Nakagami H, Schlögelhofer P, Grelon M, Schnittger A* The Arabidopsis Cdk1/Cdk2 homolog CDKA;1 controls the chromosome axis assembly during plant meiosis. The EMBO Journal , 2020, 39(3): e101625.（Cover story）.
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