Click:   The Last Update Time:--

Chao Yang

Supervisor of Doctorate Candidates
Name (Simplified Chinese):Chao Yang
Name (English):Chao Yang
Name (Pinyin):Chao Yang
Administrative Position:Professor
Professional Title:Professor
Status:Employed
Education Level:With Certificate of Graduation for Doctorate Study
Degree:博士
Business Address:National Key Laboratory of Crop Genetic Improvement A323
E-Mail:
Alma Mater:University of Hamburg
Teacher College:College of Plant Sciences & Technology
School/Department:Huazhong Agricultrural University
Other Contact Information:

Email:

Paper Publications
Yuan X, Cai B, Hamamura Y, Schnittger A*, Yang C* SCFRMF-dependent degradation of the nuclear lamina releases the somatic chromatin mobility restriction for meiotic recombination. Science Advances, 2025, 11, eadr456. DOI:10.1126/sciadv.adr4567
Release time:2025-02-26    Hits:

Abstract:Meiosis prepares the genome for sexual reproduction and is a driver of genetic diversity. Essential for both aspects are rapid chromosome movements enabling the pairing of homologous chromosomes, thereby promoting their recombination and ensuring their correct segregation afterward. However, it is unknown how meiocytes reorganize their nuclear architecture when chromosomes are tethered to the nuclear lamina in somatic cells. Here, we reveal the meiosis-specific Skp1–Cul1–F-box-protein (SCF) E3 ubiquitin ligase SCFRMF as a key regulator of this reorganization in Arabidopsis. We find that the nuclear lamina proteins of the CRWN family are degraded in an SCFRMF-dependent manner in this process. Thus, the SCFRMF functions to release the somatic constraints on chromosome mobility through disrupting the nuclear lamina, allowing homologous chromosomes to pair.

Translation or Not:no

Links to published journals:https://www.science.org/doi/10.1126/sciadv.adr4567#core-collateral-metrics