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Chao Yang

Supervisor of Doctorate Candidates
Name (Simplified Chinese):Chao Yang
Name (English):Chao Yang
Name (Pinyin):Chao Yang
Administrative Position:Professor
Professional Title:Professor
Status:Employed
Education Level:With Certificate of Graduation for Doctorate Study
Degree:博士
Business Address:National Key Laboratory of Crop Genetic Improvement A323
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Alma Mater:University of Hamburg
Teacher College:College of Plant Sciences & Technology
School/Department:Huazhong Agricultrural University
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Paper Publications
Zhang Y, Lv, F, Wan Z, Geng M, Chu L, Cai B, Zhuang J, Ge X, Schnittger A, Yang C* The synaptonemal complex stabilizes meiosis in allotetraploid Brassica napus and autotetraploid Arabidopsis thaliana. New Phytologist, 2025 https://doi.org/10.1111/nph.70015
Release time:2025-02-26    Hits:

Abstract:Polyploidy plays a key role in genome evolution and crop improvement. The formation of bivalents rather than multivalents during meiosis of polyploids is essential to ensure meiotic stability and optimal fertility of the species. However, the mechanisms preventing multivalent recombination in polyploids remain obscure. We studied the role of the synaptonemal complex in polyploid meiosis by mutating the transverse filament component ZYP1 in allotetraploid Brassica napus and autotetraploid Arabidopsis. In B. napus, a mutation of all four ZYP1 copies results in multivalent pairing accompanied by pairing partner switches, nonhomologous recombination, and interlocks, leading to severe chromosome entanglement and fertility abortion. The presence of only one functional allele of ZYP1 compromises synapsis and multivalent associations occur at nonsynaptic regions. Moreover, the disruption of ZYP1 causes a complete shift from predominantly multivalent pairing to exclusively multivalent pairing in pachytene cells of synthetic autotetraploid Arabidopsis thaliana, resulting in a dramatic increase in the frequency of multivalents at metaphase I. We conclude that the ZYP1-mediated assembly of the synaptonemal complex facilitates the pairwise homologous pairing and recombination in both allopolyploid and autopolyploid species and plays a key role in ensuring a diploid-like bivalent formation in polyploid meiosis.

Translation or Not:no

Links to published journals:https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.70015