周锐，男，华中农业大学二级岗教授、博士生导师。兼任科技部动物疾病防控国际联合研究中心主任、华中农业大学-回盛研究院院长、湖北洪山实验室-回盛生物联合研究院院长、中国兽医协会教育工作委员会委员等。国家“973计划”和国家重点研发计划项目首席科学家，入选教育部“新世纪优秀人才支持计划”，湖北省杰出青年科学基金获得者，湖北省自然科学基金创新研究群体学术带头人。主要从事动物和人兽共患病原细菌的病原生物学、生长代谢与毒力调控机制、药物、疫苗和诊断试剂及综合防控技术研究。与英国剑桥大学、帝国理工学院、伦敦大学等建立了紧密的科学研究与人才培养合作关系。先后主持国家“973计划”、“863计划”、国家重点研发计划、国家转基因生物新品种培育重大专项、国家自然科学基金面上项目和国际组织间重点合作项目、国家国际科技合作专项、教育部重大科技项目、湖北省生物技术重大项目、中英合作项目等20余项。在Advanced Science、Small、Engineering、Journal of Bacteriology、Infection and Immunity、Virulence、Veterinary Microbiology、Environmental Microbiology、BMC Microbiology、Journal of Immunology、Antibiotics、Antiviral Research等学术期刊上发表论文200余篇。获国家重点新产品证书1项、国家新兽药注册证书3项、授权发明专利10项，制定湖北省地方标准1项，获湖北省科学技术进步一等奖2项、湖北省教学成果一等奖1项、国家教学成果二等奖1项。

Selected publications:

[1]        Li T, Liu X, Zhang L, Li H, Ni M, Zou W, Liang M, Gong R, Hu Q, Zhao L, Hu Z, Li L, Huang Q*, Zhou R*. EzrA promotes Z-ring formation through interaction of its QNR motif with FtsA. J Bacteriol. 2025 Jul 24;207(7):e0012525. doi: 10.1128/jb.00125-25.

[2]        Gao T, Li T, Zhu J, Zheng L, Chen M, Liu W, Yang K, Zhang T, Yuan F, Liu Z, Guo R, Li C, Wu Q, Tian Y, Zhou R*, Zhou D*. Identification of SepF in Streptococcus suis involving cell division. BMC Microbiol. 2025 Mar 31;25(1):179. doi: 10.1186/s12866-025-03919-3.

[3]        Yan C, Tao Y, Fan J, Dai J, Li S, Huang Q*, Zhou R*. Generation and characterization of two acid-resistant macrocin O-methyltransferase variants with a higher enzyme activity at 30°C from Streptomyces fradiae. Comput Struct Biotechnol J. 2024 Aug 22;23:3232-3240. doi: 10.1016/j.csbj.2024.08.020.

[4]        Xu J, Chen L, Pang S, Zhang Q, Deng S, Zhu J, Chen X, Langford PR, Huang Q, Zhou R*, Li L*. HylS', a fragment of truncated hyaluronidase of Streptococcus suis, contributes to immune evasion by interaction with host complement factor C3b. Virulence. 2024 Feb; 15(1): 2306691. doi: 10.1080/21505594.2024.2306691.

[5]        Jiang Q, Li B, Zhang L, Li T, Hu Q, Li H, Zou W, Hu Z, Huang Q*, Zhou R*. DivIVA interacts with the cell wall hydrolase MltG to regulate peptidoglycan synthesis in Streptococcus suis. Microbiol Spectr. 2023 Jun 15;11(3):e0475022. doi: 10.1128/spectrum.04750-22.

[6]        Zou G, Matuszewska M, Jia M, Zhou J, Ba X, Duan J, Zhang C, Zhao J, Tao M, Fan J, Zhang X, Jin W, Cui T, Zeng X, Jia M, Qian X, Huang C, Zhuo W, Yao Z, Zhang L, Li S, Li L, Huang Q, Wu B, Chen H, Tucker AW, Grant AJ, Holmes MA*, Zhou R*. A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal methicillin-resistant Staphylococcus aureus populations. Adv Sci (Weinh). 2022 Feb; 9(4): e2103388. doi: 10.1002/advs.202103388.

[7]        Peng F, Xiang Y, Wang H, Hu Y, Zhou R*, Hu Y*. Biomimetic assembly of Spore@ZIF-8 microspheres for vaccination. Small. 2022 Aug 22:e2204011. doi: 10.1002/smll.202204011.

[8]        Huang J, Liu X, Sun Y, Huang C, Wang A, Xu J, Zhou H, Li L*, Zhou R*. Porcine β-defensin 2 confers enhanced resistance to swine flu infection in transgenic pigs and alleviates swine influenza virus-induced apoptosis possibly through interacting with host SLC25A4. Antiviral Res. 2022 Mar 24: 105292. doi: 10.1016/j.antiviral.2022.105292.

[9]        Tan MF#, Hu Q#, Hu Z, Zhang CY, Liu WQ, Gao T, Zhang LS, Yao L, Li HQ, Zeng YB, Zhou R*. Streptococcus suis MsmK: Novel cell division protein interacting with FtsZ and maintaining cell shape. mSphere. 2021 Mar 17; 6(2): e00119-21. doi: 10.1128/mSphere.00119-21.

[10]    Huang J, Wang A, Huang C, Sun Y, Song B, Zhou R*, Li L*. Generation of marker-free pbd-2 knock-in pigs using the CRISPR/Cas9 and Cre/loxP systems. Genes (Basel). 2020 Aug 18;11(8):951. doi: 10.3390/genes11080951.

[11]    Yang X, Cheng YT, Tan MF, Zhang HW, Liu WQ, Zou G, Zhang LS, Zhang CY, Deng SM, Yu L, Hu XY, Li L, Zhou R*. Overexpression of porcine beta-defensin 2 enhances resistance to Actinobacillus pleuropneumoniae infection in pigs. Infect Immun. 2015 July, 83(7): 2836-2843.

[12]    Li W, WanY, Tao Z, Chen HC, Zhou R*. A novel fibronectin-binding protein of Streptococcus suis serotype 2 contributes to epithelial cell invasion and in vivo dissemination. Vet Microbiol, 2013, 162(1): 186-194.

[13]    Zhang TF, Ding Y, Li TT, Wan Y, Li W, Chen HC, Zhou R*. A fur-like protein PerR regulates two oxidative stress response related operons dpr and metQIN in Streptococcus suis. BMC Microbiol. 2012, 12: 85.

[14]    Xu Z, Chen H*, Zhou R*. Genome-wide evidence for positive selection and recombination in Actinobacillus pleuropneumoniae. BMC Evol Biol. 2011, 11: 203.

[15]    Xu ZF, Chen XB, Li L, Li TT, Wang SY, Chen HC, Zhou R*. Comparative genomic characterization of Actinobacillus pleuropneumoniae. J Bacteriol. 2010, 192(21): 5625-5636.

[16]    Jin H, Wan Y, Zhou R*, Li LJ, Luo R, Zhang SH, Hu JY, Langford PR, Chen HC*. Identification of genes transcribed by Haemophilus parasuis in necrotic porcine lung through the selective capture of transcribed sequences (SCOTS). Environ Microbiol. 2008, 10(12), 3326-3336.

[17]    Huang HL, Zhou R*, Fan HY, Dan HB, Chen ML, Yan L, Bei WC, Chen HC. Generation of monoclonal antibodies and epitope mapping of ApxIVA of Actinobacillus pleuropneumoniae. Mol Immunol. 2006, 43(13): 2130-2134.

[18]    Jin H, Zhou R*, Kang MS, Cai XW, Chen HC. Biofilm formation by field isolates and reference strains of Haemophilus parasuis. Vet Microbiol. 2006, 118(1-2): 117-123.

[19]    Zhou R, Heinrich F, Schneider MR, Lahm H, Hoeflich A, Wanke R & Wolf E*. Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice. J Mol Endocrinol. 2004, 32(2): 349-364.

[20]    Zhou R*, Diehl D, Hoeflich A, Lahm H & Wolf E. IGF-binding protein-4: biochemical characteristics and functional consequences. J Endocrinol. 2003, 178(2): 177-193. 

国家新兽药注册证书：

[1]   国家新兽药注册证书，猪传染性胸膜肺炎三价灭活疫苗（2006新兽药证字68号）

[2]   国家重点新产品证书，猪传染性胸膜肺炎三价灭活疫苗（2009GRD11001）

[3]   国家新兽药注册证书，猪胸膜肺炎放线杆菌ApxIV-ELISA抗体检测试剂盒（2010新兽药证字49号）

[4]   国家新兽药注册证书，泰地罗新注射液（2021新兽药证字02号）