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Supervisor of Doctorate Candidates
Supervisor of Master's Candidates
Name (Simplified Chinese):周锐
Name (Pinyin):Zhou Rui
School/Department:Huazhong Agricultural University College of Veterinary Medicine
Administrative Position:Professor
Education Level:With Certificate of Graduation for Doctorate Study
Business Address:Room A311, The 4th Multi-functional Building No. 1, Shizishan Street, 430070 Wuhan, China
Degree:Doctoral degree
Professional Title:Professor
Academic Titles:Director of International Research Center for Animal Disease (IRCAD)
Other Post:中国兽医协会教育工作委员会委员
Alma Mater:University of Munich, Germany
Teacher College:College of Animal Sciences & Technology / College of Veterinary Medicine
Discipline:Preventive Veterinary Medicine    
Other Contact Information:







周锐,男,华中农业大学二级岗教授、博士生导师。兼任科技部动物疾病防控国际联合研究中心主任、华中农业大学-回盛研究院院长、中国兽医协会教育工作委员会委员。入选教育部新世纪优秀人才支持计划,湖北省杰出青年科学基金获得者,国家973计划和国家重点研发计划项目首席科学家,湖北省自然科学基金猪细菌病的病原生物学与致病机理创新研究群体学术带头人。主要从事动物细菌性传染病的流行病学、病原生物学与防控技术研究。与英国剑桥大学、帝国理工学院建立了紧密的科学研究与人才培养合作关系。先后主持973计划、863计划、国家重点研发计划、国家转基因生物新品种培育重大专项、国家自然科学基金面上项目和国际组织间重点合作项目、国家国际科技合作专项、教育部重大科技项目、湖北省生物技术重大项目、中英合作项目等20余项。在Advanced ScienceSmallEngineeringJournal of BacteriologyInfection and ImmunityVirulenceVeterinary MicrobiologyEnvironmental MicrobiologyBMC MicrobiologyJournal of ImmunologyAntibioticsAntiviral Research等学术期刊上发表论文190余篇。获国家重点新产品证书1项、国家新兽药注册证书3项、授权发明专利10项,制定湖北省地方标准1项,获湖北省科学技术进步一等奖2项、国家教学成果二等奖1项、湖北省教学成果一等奖1项。


Selected publications:

1.       Qiu XX, Luo WT, Li HT, Li TT, Huang YX, Huang Q*, Zhou R*. A traditional Chinese medicine, Zhenqi Granule, potentially alleviates dextran sulfate sodium-induced mouse colitis symptoms. Biology. 2024, Jun 10; 13, 427.

2.       Xu J, Chen L, Pang S, Zhang Q, Deng S, Zhu J, Chen X, Langford PR, Huang Q, Zhou R*, Li L*. HylS', a fragment of truncated hyaluronidase of Streptococcus suis, contributes to immune evasion by interaction with host complement factor C3b. Virulence. 2024 Feb;15(1):2306691.

3.       Shi H, Luo W, Wang S, Dai J, Chen C, Li S, Liu J, Zhang W, Huang Q, Zhou R*. Therapeutic efficacy of tylvalosin combined with Poria cocos polysaccharides against porcine reproductive and respiratory syndrome. Front Vet Sci. 2023 Aug 7:10:1242146.

4.       Jiang Q, Li B, Zhang L, Li T, Hu Q, Li H, Zou W, Hu Z, Huang Q*, Zhou R*. DivIVA interacts with the cell wall hydrolase MltG to regulate peptidoglycan synthesis in Streptococcus suis. Microbiol Spectr. 2023 Jun 15;11(3):e0475022. doi: 10.1128/spectrum.04750-22.

5.       Fan J, Yao Z, Yan C, Hao M, Dai J, Zou W, Ni M, Li T, Li L, Li S, Liu J, Huang Q*, Zhou R*. Discovery of a highly efficient TylF methyltransferase via random mutagenesis for improving tylosin production. Comput Struct Biotechnol J. 2023 Apr 20; 21:2759-2766.

6.       Zou G, Matuszewska M, Jia M, Zhou J, Ba X, Duan J, Zhang C, Zhao J, Tao M, Fan J, Zhang X, Jin W, Cui T, Zeng X, Jia M, Qian X, Huang C, Zhuo W, Yao Z, Zhang L, Li S, Li L, Huang Q, Wu B, Chen H, Tucker AW, Grant AJ, Holmes MA*, Zhou R*. A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal methicillin-resistant Staphylococcus aureus populations. Adv Sci (Weinh). 2022 Feb; 9(4): e2103388.

7.       Peng F, Xiang Y, Wang H, Hu Y, Zhou R*, Hu Y*. Biomimetic Assembly of Spore@ZIF-8 Microspheres for Vaccination. Small. 2022 Aug 22:e2204011.

8.       Huang J, Liu X, Sun Y, Huang C, Wang A, Xu J, Zhou H, Li L*, Zhou R*. Porcine β-defensin 2 confers enhanced resistance to swine flu infection in transgenic pigs and alleviates swine influenza virus-induced apoptosis possibly through interacting with host SLC25A4. Antiviral Res. 2022 Mar 24: 105292.

9.       Li H, Li T, Zou W, Ni M, Hu Q, Qiu X, Yao Z, Fan J, Li L, Huang Q*, Zhou R*. IPA-3: An inhibitor of diadenylate cyclase of Streptococcus suis with potent antimicrobial activity. Antibiotics (Basel). 2022; 11(3): 418.

10.     Luo W, Huang Y, Qiu X, Zhuo W, Tao Y, Wang S, Li H, Shen J, Zhao L, Zhang L, Li S, Liu J, Huang Q*, Zhou R*. Growth-promoting effects of Zhenqi granules on finishing pigs. Animals (Basel). 2022 Dec 13;12(24):3521. doi: 10.3390/ani12243521.

11.     Huang C, Sun Y, Qiu X, Huang J, Wang A, Zhang Q, Pang S, Huang Q, Zhou R, Li L*. The intracellular interaction of porcine β-defensin 2 with VASH1 alleviates inflammation via Akt signaling pathway. J Immunol. 2022 Jun 10: ji2100810.

12.     Tang H, Zhang Q, Han W, Wang Z, Pang S, Zhu H, Tan K, Liu X, Langford PR, Huang Q, Zhou R, Li L*. Identification of FtpA, a Dps-like protein involved in anti-oxidative stress and virulence in Actinobacillus pleuropneumoniaeJ Bacteriol. 2022 Feb 15; 204(2): e0032621.

13.     Tan MF#, Hu Q#, Hu Z, Zhang CY, Liu WQ, Gao T, Zhang LS, Yao L, Li HQ, Zeng YB, Zhou R*. Streptococcus suis MsmK: novel cell division protein interacting with FtsZ and maintaining cell shape. mSphere. 2021 Mar 17; 6(2): e00119-21.

14.     Deng S, Zhao L, Zhu J, Chen L, Zhou R*. Complement C3aR/C5aR-binding protein suilysin of Streptococcus suis contributes to monocyte chemotaxis. Vet Microbiol. 2020 Mar; 242:108599.

15.     Huang J, Wang A, Huang C, Sun Y, Song B, Zhou R*, Li L*. Generation of marker-free pbd-2 knock-in pigs using the CRISPR/Cas9 and Cre/loxP systems. Genes (Basel). 2020 Aug 18;11(8):951.

16.     Huang J, Yang X, Wang A, Huang C, Tang H, Zhang Q, Fang Q, Yu Z, Liu X, Huang Q, Zhou R*, Li L*. Pigs overexpressing porcine β-defensin 2 display increased resilience to Glaesserella parasuis infection. Antibiotics (Basel). 2020 Dec 14;9(12):903.

17.     Huang J, Qi Y, Wang A, Huang C, Liu X, Yang X, Li L*, Zhou R*. Porcine β-defensin 2 inhibits proliferation of pseudorabies virus in vitro and in transgenic mice. Virol J. 2020 Feb 3;17(1):18. doi: 10.1186/s12985-020-1288-4.

18.     Chao Nguyen Van, Lijun Zhang, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, Qi Huang*, Rui Zhou*. Association between the phenotypes and genotypes of antimicrobial resistance in Haemophilus parasuis isolates from swine in Quang Binh and Thua Thien Hue Provinces, Vietnam. Engineering. 2020 Feb; 6: 40-48.

19.     Huang C, Yang X, Huang J, Liu X, Yang X, Jin H, Huang Q, Li L*, Zhou R*. Porcine beta-defensin 2 provides protection against bacterial infection by a direct bactericidal activity and alleviates inflammation via interference with the TLR4/NF-κB pathway. Front Immunol. 2019 Jul 18; 10:1673.

20.     Van CN, Thanh TVT, Zou G, Jia M, Wang Q, Zhang L, Ding W, Huang Q, Zhou R*. Characterization of serotypes and virulence genes of Haemophilus parasuis isolates from Central Vietnam. Vet Microbiol. 2019 Mar:230:117-122.

21.     Lin L, Xu L, Lv W, Han L, Xiang Y, Fu L, Jin M, Zhou R, Chen H, Zhang A. An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS). PLoS Pathogens. 2019 Jun 6;15(6): e1007795.

22.     Peng Z, Wang X, Zhou R, Chen H, Wilson BA, Wu B. Pasteurella multocida: Genotypes and Genomics. Microbiol Mol Biol Rev. 2019 Sep 4;83(4). pii: e00014-19.

23.     Deng S, Xu T, Fang Q, Yu L, Zhu J, Chen L, Liu J, Zhou R*. The surface-exposed protein SntA contributes to complement evasion in zoonotic Streptococcus suisFront Immunol. 2018 May 16; 9:1063.

24.     Zou G, Zhou J, Xiao R, Zhang L, Cheng Y, Jin H, Li L, Zhang L, Wu B, Qian P, Li S, Ren L, Wang J, Oshota O, Hernandez-Garcia J, Wileman TM, Bentley S, Weinert L, Maskell DJ, Tucker AWD*, Zhou R*. Effects of environmental and management-associated factors on prevalence and diversity of Streptococcus suis in clinically healthy pig herds in China and the United Kingdom. Appl Environ Microbiol. 2018 Apr 2;84(8):e02590-17.

25.     Li S, Su Z, Zhang C, Xu Z, Chang X, Zhu J, Xiao R, Li L*, Zhou R*. Identification of drug target candidates of the swine pathogen Actinobacillus pleuropneumoniae by construction of protein-protein interaction network. Gen Genom. 2018 Aug;40(8):847-856.

26.     Zhang TF, Zhu JW, Wei S, Luo QP, Li L, Li SQ, Tucker A, Shao HB, Zhou R*. The roles of RelA/(p)ppGpp in glucose-starvation induced adaptive response in the zoonotic Streptococcus suisSci Rep. 2016, Jun 3; 6: 27169. doi: 10.1038/srep27169.

27.     Zhu JW, Zhang TF, Su ZP, Li L, Wang D, Xiao R, Teng MY, Tan MF, Zhou R*. (p)ppGpp synthetases regulate the pathogenesis of zoonotic Streptococcus suisMicrobiol Res. 2016 Oct:191:1-11.

28.     Zhuofei Xu, Rui Zhou*. Genome-wide detection of selection and other evolutionary forces. Methods in Molecular Biology 2015, vol. 1231, page 271-287. [Book chapter: Mengoni A, Fondi M, Galardini M ed. Bacterial Pangenomics - Methods and Protocols. Humana Press. 2015].

29.     Yang X, Cheng YT, Tan MF, Zhang HW, Liu WQ, Zou G, Zhang LS, Zhang CY, Deng SM, Yu L, Hu XY, Li L, Zhou R*. Overexpression of porcine beta-defensin 2 enhances resistance to Actinobacillus pleuropneumoniae infection in pigs. Infect Immun. 2015 Jul;83(7):2836-43.

30.     Chen Y, Liu T, Langford P, Hua K, Zhou S, Zhai Y, Xiao H, Luo R, Bi D, Jin H*, Zhou R*. Haemophilus parasuis induces activation of NF-κB and MAP kinase signaling pathways mediated by toll-like receptors. Mol Immunol. 2015 Jun;65(2):360-366.

31.     Chen Y, Zhou S, Hua K, Xiao H, Li Z, Liu M, Luo R, Bi D, Zhou R*, Jin H*. Haemophilus parasuis infection activates chemokine RANTES in PK-15 cells. Mol Immunol. 2015 Oct;67(2 Pt B):661-666.

32.     Li W, WanY, Tao Z, Chen HC, Zhou R*. A novel fibronectin-binding protein of Streptococcus suis serotype 2 contributes to epithelial cell invasion and in vivo dissemination. Vet Microbiol, 2 2013 Feb 22;162(1):186-194.

33.     Zhou Y, Li L, Chen ZH, Yuan H, Chen HC, Zhou R*. Adhesion protein ApfA of Actinobacillus pleuropneumoniae is required for pathogenesis and is a potential target for vaccine development. Clin Vaccine Immunol. 2013 Feb;20(2):287-94.

34.     Li L, Sun LL, Song YF*, Wu XJ, Zhou X, Liu ZD, Zhou R*. Screening of Actinobacillus pleuropneumoniae LuxS inhibitors. Curr Microbiol. 2013 Nov;67(5):564-71.

35.     Zhang TF, Ding Y, Li TT, Wan Y, Li W, Chen HC, Zhou R*. A fur-like protein PerR regulates two oxidative stress response related operons dpr and metQIN in Streptococcus suisBMC Microbiol. 2012 May 30:12:85.

36.     Chen YS, Jin H*, Li ZL, Meng XR, Liu M, Li SW, Shi DS, Xiao YC, Wang XL, Zhou ZT, Bi DR, Zhou R*. Haemophilus parasuis infection activates the NF-κB pathway in PK-15 cells through IκB degradation. Vet Microbiol, 2012 Nov 9;160(1-2):259-63.

37.     Xu Z, Chen H*, Zhou R*. Genome-wide evidence for positive selection and recombination in Actinobacillus pleuropneumoniaeBMC Evol Biol. 2011, Jul 13:11:203.

38.     129. Xu ZF, Chen XB, Li L, Li TT, Wang SY, Chen HC, Zhou R*. Comparative genomic characterization of Actinobacillus pleuropneumoniaeJ Bacteriol. 2010 Nov; 192(21):5625-36.

39.     Jin H, Wan Y, Zhou R*, Li LJ, Luo R, Zhang SH, Hu JY, Langford PR, Chen HC*. Identification of genes transcribed by Haemophilus parasuis in necrotic porcine lung through the selective capture of transcribed sequences (SCOTS). Environ Microbiol. 2008 Dec;10(12):3326-36.

40.     Huang HL, Zhou R*, Fan HY, Dan HB, Chen ML, Yan L, Bei WC, Chen HC. Generation of monoclonal antibodies and epitope mapping of ApxIVA of Actinobacillus pleuropneumoniaeMol Immunol. 2006 May;43(13):2130-4.

41.     Jin H, Zhou R*, Kang MS, Cai XW, Chen HC. Biofilm formation by field isolates and reference strains of Haemophilus parasuisVet Microbiol. 2006 Nov 26;118(1-2):117-23.

42.     Zhou R, Heinrich F, Schneider MR, Lahm H, Hoeflich A, Wanke R & Wolf E*. Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice. Journal of Mol Endocrinol. 2004 Apr;32(2):349-64.

43.     Zhou R*, Diehl D, Hoeflich A, Lahm H & Wolf E. IGF-binding protein-4: biochemical characteristics and functional consequences. J Endocrinol. 2003 Aug;178(2):177-93.

Educational Experience

[1] 1999.10——2003.7
德国慕尼黑大学 > Doctoral Degree in Agriculture > With Certificate of Graduation for Doctorate Study
[2] 1993.9——1995.12
华中农业大学 > Master's Degree in Agriculture > 农学硕士学位
[3] 1988.9——1993.7
华中农业大学 > Bachelor's Degree in Agriculture > 农学学士学位

Work Experience

[1] 2007.11-Now
华中农业大学 > 动物医学院预防兽医学系 > 教授
[2] 2003.11-2007.10
华中农业大学 > 动物医学院预防兽医学系 > 副教授
[3] 1998.11-1999.9
华中农业大学 > 动物医学院预防兽医学系 > 讲师
[4] 1996.4-1998.10
华中农业大学 > 动物医学院预防兽医学系 > 助教

Social Affiliations

[1] 2016.1-Now
[2] 2021.10-Now

Research Group
Name of Research Group:动物细菌病病原生物学与防控技术

Description of Research Group:本团队为湖北省自然科学基金创新群体。
成员:周锐教授  黎璐副教授  黄琦副研究员  张梁盛博士(博士后)  姜婷婷(科研助理)

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