Liang Ronghong
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Scientific Research
The research group is dedicated to integrating fundamental research with gene editing technologies to develop biotechnologies that safeguard human health. The team focuses on pioneering original gene editing technologies and establishing gene editing systems with independent intellectual property rights in China, with a particular emphasis on prime editing. Prime editing enables all types of single-base conversions, facilitates arbitrary editing of small DNA fragments, and can be combined with recombinases to achieve large-scale edits, including chromosome editing. To address current bottlenecks in crop breeding, the group is committed to developing "obligate apomixis" in crops, where both embryos and endosperm are completely independent of pollen fertilization, thereby resolving challenges in hybrid seed production. Additionally, the team is working on apomixis-based breeding technologies for crops that are currently difficult to improve through hybridization. For vegetatively propagated crops, the aim is to convert them into apomixis-based, virus-free clonal seed propagation systems, revolutionizing agricultural practices and enabling automated production.
- 1. Ronghong Liang; Zixin He; Kevin Tianmeng Zhao; Haocheng Zhu; Jiacheng Hu; Guanwen Liu; Qiang Gao; Meiyan Liu; Rui Zhang; Jin-Long Qiu; Caixia Gao; Prime editing using CRISPR-Cas12a and circular RNAs in human cells, Nature Biotechnology, 2024, 42(12): 1867-1875.
- 2. Ronghong Liang; Shan Wang; Yibo Cai; Zhenyu Li; Ka Ming Li; Jingjing Wei; Chao Sun; Haocheng Zhu; Kunling Chen; Caixia Gao; Circular RNA-mediated inverse prime editing in human cells, Nature Communications, 2025, 16(1): 5057.
- 3. Ronghong Liang; Caixia Gao; Creating one-line hybrid crops by synthetic apomixis, Molecular Plant, 2024, 17(1): 16-18.
- 4. Haocheng Zhu; Xu Qin; Leyan Wei; Dandan Jiang; Qiao Zhang; Wenqian Wang; Ronghong Liang; Rui Zhang; Kang Zhang; Guanwen Liu; Kevin Tianmeng Zhao; Kunling Chen; Jin-Long Qiu; Caixia Gao; Engineered geminivirus replicons enable rapid in planta directed evolution, Science, 2025, 390(6774).
- 5. Shuai Jin; Zixu Zhu; Yunjia Li; Shouyue Zhang; Yijing Liu; Danyuan Li; Yuanqing Li; Yingfeng Luo; Zhiheng Cheng; Kevin Tianmeng Zhao; Qiang Gao; Guanglei Yang; Hongchao Li; Ronghong Liang; Rui Zhang; Jin-Long Qiu; Yong E. Zhang; Jun-Jie Gogo Liu; Caixia Gao; Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons, Cell, 2025, 188(22): 6283-6300.
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- 4. 盖茨基金会, 国际合作项目, INV-069019, Delivering synthetic apomictic rice to small holder farmers in Africa, 2024-11 至 2028-10, 1000万元, 在研, 参与
- 3. 国家自然科学基金委员会, 青年科学基金项目（C类）[原青年科学基金项目], 32401242, 开发环状RNA介导的反向引导编辑系统, 2025-01-01 至 2027-12-31, 30万元, 在研, 主持
- 2. 中国生物技术发展中心, 国家重点研发计划子课题, 2024YFA0917303-03, 适用于植物的高效精准大片段DNA操纵技术的研发，相关作物新种质的创制, 2024-12 至 2029-11, 200万元, 在研, 主持
- 1. 农业农村部科技发展中心, 农业生物育种国家科技重大专项子课题, 2023ZD0407401-04, 基因大片段精准编辑技术研发与在水稻中的应用, 2023-12 至 2025-12, 248万元, 结题, 主持
