周雄辉，男，1986年3月出生于四川遂宁市，2009年6月获得暨南大学计算机科学与技术系工学学士，2009年9月开始于武汉大学计算机学院硕博连读，研究方向为生物信息学，并于2014年6月获得工学博士学位。并于2019年4月到2020年10月在辛辛那提儿童医院医学中心做研究员，进行液体活检领域的研究。现在为华中农业大学信息学院副教授。近年来主要从事系统生物学和数据挖掘的研究，具体的研究领域为癌症系统生物学。

主要的科研课题和论文如下：

主持项目：

1. 基于DNA甲基化交互网络的癌症hallmark挖掘及其在癌症转移biomarker筛选中的应用，国家自然科学基金 (61602201), 2017.1-2019.12, 20万，主持。

2. 基于DNA甲基化交互网络的癌症hallmark挖掘及其在癌症预后中的应用研究，湖北省自然科学基金 (2016CFB139), 2016.1-2017.12, 5万，主持。

3.基于GeneRank的乳腺癌亚型精准医疗(09002021122),校自主科研基金，2018.1-2020.12, 30万，主持。

以主要作者发表的论文：

1. Xionghui Zhou, Yaping Liu*. De novo characterization of cell-free DNA fragmentation hotspots boosts the power for early detection and localization of multi-cancer. BioRxiv. 2020 (Preprint)

2. He-Gang Chen, Xiong-Hui Zhou*. MNBDR: A Module Network Based Method for Drug Repositioning. Genes. 2021; 12(1): 25. (SCI, IF=3.759)

3. Lu Bo, Xiong-Hui Zhou*. Ensemble Classifier based on gene synergistic network improves breast cancer outcome prediction. IEEE International Conference on Bioinformatics and Biomedicine (BIBM). 2019; 207-210. (CCF B类会议)

4. Xiong-Hui Zhou, Xin-Yi Chu, Gang Xue, Jiang-Hui Xiong, Hong-Yu Zhang*.(2019) Identifying cancer prognostic modules by module network analysis. Bmc Bioinformatics 20 2019,20:85. (SCI, IF=2.213, CCF C类期刊)

5. Ze-Jia Cui, Xiong-Hui Zhou*, Hong-Yu Zhang*. DNA Methylation Module Network-Based Prognosis and Molecular Typing of Cancer. Genes. 2019; 10(8): 571. (SCI, IF=3.759)

6. Jia-Nuo Li#, Rui Zhong#, and Xiong-Hui Zhou*. Prediction of bone metastasis in breast cancer based on minimal driver gene set in gene dependency network. Genes. 2019; 10(6): 466. (SCI, IF=3.759)

7. Gao Yi-Cheng, Xiong-Hui Zhou* and Wen Zhang*. An ensemble strategy to predict prognosis in ovarian cancer based on gene modules. Frontiers in genetics. 2019; 10:366. (SCI, IF=4.151)

8. Ling-Hao Yu, Qin-Wei Huang, Xiong-Hui Zhou*. (2019) Identification of Cancer Hallmarks Based on the Gene Co-expression Networks of Seven Cancers. Frontiers in Genetics 2019,10: https://doi.org/10.3389/fgene.2019.00099.(SCI, IF=4.151)

9. Wei-Lin Hu, Xiong-Hui Zhou*. (2017) Identification of prognostic signature in cancer based on DNA methylation interaction network. Bmc Medical Genomics, 2017, 10(4):63. (SCI, IF=3.32)

10. Xin-Yi Chu, Ling-Han Jiang , Xiong-Hui Zhou*, Ze-Jia Cui and Hong-Yu Zhang. (2017) Evolutionary Origins of Cancer Driver Genes and Implications for Cancer Prognosis. Genes, 2017,8(7). (SCI, IF=3.19)

11. Jianyong Wang, Lingling Chen, Xiong-Hui Zhou*. (2017) Identifying prognostic signature in ovarian cancer using DirGenerank. Oncotarget, 2017,doi: 10.18632/oncotarget.18189. (SCI, IF=5.168)

12. Xiwen Xu#, Xiong-Hui Zhou#, Ruiru Wang, Wenlei Peng, Yue An, Lingling Chen*. (2016) Functional analysis of long intergenic non-coding RNAs in phosphate starved rice using competing endogenous RNA network, Scientific Reports 6, 2016, doi: 10.1038/srep20715. (SCI, IF=4.259)

13. Xionghui Zhou，Juan Liu. (2014) Inferring gene dependency network specific to phenotypic alteration based on gene expression data and clinical information of breast cancer. PLoS ONE 9(3): e92023. (SCI, IF=3.573)

14. Xionghui Zhou, Juan Liu. (2014) A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways. BMC Cancer 2014, 14:618. (SCI, IF=3.36)

15. Xionghui Zhou, Juan Liu, Wei Wang. (2014) Construction and investigation of breast-cancer-specific ceRNA network based on the mRNA and miRNA expression data. IET systems biology 8(3):pp.96-103. (SCI, IF=1.535, 期刊热点论文)

16. Xionghui Zhou, Juan Liu, Xinhuo Ye, Wei Wang, Jianghui Xiong. (2013) Ensemble classifier based on context specific miRNA regulation modules: a new method for cancer outcome prediction. BMC Bioinformatics, 14(Suppl 12):S6. (SCI, IF=3.02, CCF C类期刊)  

17. Xionghui Zhou, Juan Liu, Jianghui Xiong. (2012) Predicting distant metastasis in breast cancer using ensemble classifier based on context specific miRNA regulation modules, 2012 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). pp. 1-6. (CCF B类会议，Regular paper).

18. Xionghui Zhou, Juan Liu, Changning Liu, Rayner, S., Fengji Liang, Jingfang Ju, Yinghui Li, Shanguang Chen, Jianghui Xiong. (2011) Context-Specific miRNA Regulation Network Predicts Cancer Prognosis. IEEE international conference on system biology (ISB), 2011, pp. 225-243 (EI).