Abiotic stresses such as drought, high salinity, and extreme temperature cause extensive losses to agricultural production worldwide due to the global climate change, fresh water shortage, cropland decrease and increasing population. Plants have evolved a range of physiological, biochemical, and molecular responses to confer tolerance to these environmental stresses. Our lab is interested in understanding the molecular mechanism of how plants response to abiotic stress in rice. We applied traditional forward genetics, reverse genetics and GWAS to identifying key regulators in abiotic stress of rice. We wish to eventually improve the production of rice under these abiotic stress that can help us to solving the problem of uncorrelated increasing rate between human population and cereal yield in the future.