王茂军,中共党员,教授、博士生导师。2007-2017年就读于华中农业大学,先后获得学士、博士学位;2018-2019年在美国农业部南方研究中心开展访学研究。面向国家重大需求——优质棉花纤维严重短缺这一产业问题,一直从事棉花纤维发育和品质形成的遗传研究,在棉花基因组演化和驯化、纤维发育和品质形成调控生物学等方面取得多个创新性成果,致力于为优质棉基因组育种提供理论基础和技术手段。以通讯或第一作者在Nature Genetics、Nature Plants、Genome Biology、Nucleic Acids Research、Molecular Biology and Evolution、Trends in Plant Science等期刊发表论文30余篇,其中10篇入选期刊封面论文、ESI高被引论文或被F1000推荐,部分研究论文入选“2017年中国农业科学重大进展”、“2019年中国百篇最具影响国际学术论文”,授权国家发明专利/软件著作权5件。获国家自然科学基金委“优青”(2019)、农业农村部青年人才项目(2023)等资助。担任BMC Biology等期刊编委、国际棉花基因组协会共同主席、中国农学会棉花分会副秘书长、湖北省青联第十四届委员会教育与社科界别副主任委员等职务。
主持国家自然科学基金、国家重点研发计划青年科学家项目、国家科技重大专项子课题、湖北省种业“揭榜怪帅”项目、中国科协青年人才托举工程等项目。获得湖北省自然科学一等奖(2/5)、神农中华农业科技奖优秀创新团队奖(5/12)、中国农学会青年科技奖、中国作物学会科学技术成就奖(青年奖)、湖北向上向善好青年等奖项或荣誉。
研究课题组立足于棉花纤维品质改良,以干实验和湿实验手段,运用基因组学、生物信息学、分子生物学、基因组编辑和人工智能等多学科手段解析棉花纤维发育和品质形成的遗传基础,揭示染色质高级结构对性状形成的调控机制,回答多倍体作物基因组演化相关的基础科学问题。
代表性论文(#共同一作,*通讯作者):
1. Jiaqi You#, Zhenping Liu#, Zhengyang Qi#, Yizan Ma#, Mengling Sun, Ling Su, Hao Niu, Yabing Peng, Xuanxuan Luo, Mengmeng Zhu, Yuefan Huang, Xing Chang, Xiubao Hu, Yuqi Zhang, Ruizhen Pi, Yuqi Liu, Qingying Meng, Jianying Li, Qinghua Zhang, Longfu Zhu, Zhongxu Lin, Ling Min, Daojun Yuan, Corrinne E. Grover, David D Fang, Keith Lindsey, Jonathan F. Wendel, Lili Tu*, Xianlong Zhang*, Maojun Wang*. Regulatory controls of duplicated gene expression during fiber development in allotetraploid cotton. Nature Genetics, 2023, 55(11):1987–1997.
2. Maojun Wang#, Jianying Li#, Zhengyang Qi#, Yuexuan Long#, Liuling Pei, Xianhui Huang, Corrinne E. Grover, Xiongming Du, Chunjiao Xia, Pengcheng Wang, Zhenping Liu, Jiaqi You, Xuehan Tian, Yizan Ma, Ruipeng Wang, Xinyuan Chen, Xin He, David D Fang, Yuqiang Sun, Lili Tu, Shuangxia Jin, Longfu Zhu, Jonathan F. Wendel*, Xianlong Zhang*. Genomic innovation and regulatory rewiring during evolution of the cotton genus Gossypium. Nature Genetics, 2022, 54(12):1959–1971.
3. Maojun Wang#, Lili Tu#, Daojun Yuan#, De Zhu, Chao Shen, Jianying Li, Fuyan Liu, Liuling Pei, Pengcheng Wang, Guannan Zhao, Zhengxiu Ye, Hui Huang, Feilin Yan, Yizan Ma, Lin Zhang, Min Liu, Jiaqi You, Yicheng Yang, Zhenping Liu, Fan Huang, Baoqi Li, Ping Qiu, Qinghua Zhang, Longfu Zhu, Shuangxia Jin, Xiyan Yang, Ling Min, Guoliang Li, Ling-Ling Chen, Hongkun Zheng, Keith Lindsey*, Zhongxu Lin*, Joshua A. Udall*, Xianlong Zhang*. Reference genome sequences of two cultivated allotetraploid cottons, Gossypium hirsutum and Gossypium barbadense. Nature Genetics, 2019, 51(2):224–229.
4. Maojun Wang, Lili Tu, Min Lin, Zhongxu Lin, Pengcheng Wang, Qingyong Yang, Zhengxiu Ye, Chao Shen, Jianying Li, Lin Zhang, Xiaolin Zhou, Xinhui Nie, Zhonghua Li, Kai Guo, Yizan Ma, Cong Huang, Shuangxia Jin, Longfu Zhu, Xiyan Yang, Ling Min, Daojun Yuan, Qinghua Zhang, Keith Lindsey*, Xianlong Zhang*. Asymmetric subgenome selection and cis-regulatory divergence during cotton domestication. Nature Genetics, 2017, 49(4):579–587.
5. Liuling Pei#, Xianhui Huang#, Zhenping Liu, Xuehan Tian, Jiaqi You, Jianying Li, David D. Fang, Keith Lindsey, Longfu Zhu, Xianlong Zhang, Maojun Wang*. Dynamic 3D genome architecture of cotton fiber reveals subgenome-coordinated chromatin topology for 4-staged single-cell differentiation. Genome Biology, 2022, 23, 45.
6. Jianying Li, Daojun Yuan, Pengcheng Wang, Qiongqiong Wang, Mengling Sun, Zhenping Liu, Huan Si, Zhongping Xu, Yizan Ma, Boyang Zhang, Liuling Pei, Lili Tu, Longfu Zhu, Ling-Ling Chen, Keith Lindsey, Xianlong Zhang, Shuangxia Jin*, Maojun Wang*. Cotton pan-genome retrieves the lost sequences and genes during domestication and selection. Genome Biology, 2021, 22, 119.
7. Yuexuan Long, Jonathan F. Wendel, Xianlong Zhang, and Maojun Wang*. Evolutionary insights into the organization of chromatin structure and landscape of transcriptional regulation in plants. Trends in Plant Science, 2023. DOI: 10.1016/j.tplants.2023.11.009.
8. Xuehan Tian, Mengyuan Ji, Jiaqi You, Yuqi Zhang, Keith Lindsey, Xianlong Zhang, Lili Tu, and Maojun Wang*. Synergistic interplay of redox homeostasis and polysaccharide synthesis promotes cotton fiber elongation. Plant Journal, 2024. DOI: 10.1111/tpj.16615.
9. Xin He, Xianhui Huang, Yuexuan Long, Zhenping Liu, Xing Chang, Xianlong Zhang, and Maojun Wang*. Tcbf: A novel user-friendly tool for pan-3D genome analysis of topologically associating domain in eukaryotic organisms. Bioinformatics, 2023, 39(9):btad576.
10. Xing Chang, Xin He, Jianying Li, Zhenping Liu, Ruizhen Pi, Xuanxuan Luo, Ruipeng Wang, Xiubao Hu, Sifan Lu, Xianlong Zhang, and Maojun Wang*. High-quality Gossypium hirsutum and Gossypium barbadense genome assemblies reveal the centromeric landscape and evolution. Plant Communications, 2023. DOI: 10.1016/j.xplc.2023.100722.
11. Yuefan Huang, Zhengyang Qi, Jianying Li, Jiaqi You, Xianlong Zhang*, Maojun Wang*. Genetic interrogation of phenotypic plasticity informs genome-enabled breeding in cotton. Journal of Genetics and Genomics, 2023, 50(12): 971–982.
12. Xianhui Huang#, Xuehan Tian#, Liuling Pei, Xuanxuan Luo, Yuqi Zhang, Xingtan Zhang, Xianlong Zhang, Longfu Zhu*, Maojun Wang*. Multi-omics mapping of chromatin interaction resolves the fine hierarchy of 3D genome in allotetraploid cotton. Plant Biotechnology Journal, 2022, 20(9):1639–1641.
13. Jiaqi You#, Min Lin#, Zhenping Liu, Liuling Pei, Yuexuan Long, Lili Tu, Xianlong Zhang, Maojun Wang*. Comparative genomic analyses reveal cis-regulatory divergence after polyploidization in cotton. The Crop Journal, 2022, 10(6):1545–1556.
14. Liuling Pei, Guoliang Li, Keith Lindsey, Xianlong Zhang, Maojun Wang*. Plant 3D genomics: the exploration and application of chromatin organization. New Phytologist, 2021, 230(5):1772–1786.
15. Zhonghua Li#, Pengcheng Wang#, Chunyuan You, Jiwen Yu, Xiangnan Zhang Feilin Yan, Zhengxiu Ye, Chao Shen, Baoqi Li, Kai Guo, Nian Liu, Gregory N. Thyssen, David D. Fang, Keith Lindsey, Xianlong Zhang, Maojun Wang*, Lili Tu*. Combined GWAS and eQTL analysis uncovers a genetic regulatory network orchestrating the initiation of secondary cell wall development in cotton. New Phytologist, 2020, 226(6):1738–1752.
16. Maojun Wang#, Jianying Li#, Pengcheng Wang, Fang Liu, Zhenping Liu, Guannan Zhao, Zhongping Xu, Liuling Pei, Corrinne E. Grover, Jonathan F. Wendel*, Kunbo Wang*, Xianlong Zhang*. Comparative genome analyses highlight transposon-mediated genome expansion and the evolutionary architecture of 3D genomic folding in cotton. Molecular Biology and Evolution, 2021, 38(9):3621–3636.
17. Maojun Wang, Pengcheng Wang, Min Lin*, Zhengxiu Ye, Guoliang Li, Lili Tu, Chao Shen, Jianying Li, Qingyong Yang*, and Xianlong Zhang*. Evolutionary dynamics of 3D genome architecture following polyploidization in cotton. Nature Plants, 2018, 4(2):90–97.
18. Maojun Wang, Pengcheng Wang, Lili Tu, Sitao Zhu, Lin Zhang, Zhonghua Li, Qinghua Zhang, Daojun Yuan, Xianlong Zhang*. Multi-omics maps of cotton fibre reveal epigenetic basis for staged single-cell differentiation. Nucleic Acids Research, 2016, 44(9):4067–4079.
19. Maojun Wang#, Pengcheng Wang#, Fan Liang, Zhengxiu Ye, Jianying Li, Chao Shen, Liuling Pei, Feng Wang, Jiang Hu, Lili Tu, Daohua He*, Xianlong Zhang*. A global survey of alternative splicing in allopolyploid cotton: landscape, complexity and regulation. New Phytologist, 2018, 217(1):163–178.
20. Maojun Wang, Daojun Yuan, Lili Tu, Wenhui Gao, Yonghui He, Haiyan Hu, Pengcheng Wang, Nian Liu, Keith Lindsey, Xianlong Zhang*. Long noncoding RNAs and their proposed functions in fibre development of cotton (Gossypium spp.). New Phytologist, 2015, 207(4):1181–1197.