王利利博士,华中农业大学研究员,博士生导师。入选“湖北省青年拔尖人才培养计划”、“武汉英才”。长期从事植物DNA损伤应答与非生物胁迫应答机理的研究,以第一作者或通讯作者在Cell Reports、New Phytologist、PNAS、 Nucleic Acid Research、 Plant, Cell & Environment、DNA repair等国际知名期刊发表一系列创新型成果,主持国家自然科学基金青年项目、面上项目、国家重点研发计划子课题、生物育种重大专项子课题以及华中农业大学高层次人才启动经费等。课题组依托于华中农业大学生命科学技术学院、华中农业大学拟南芥中心、DNA损伤修复创新团队。实验室仪器设备完善、科研氛围浓厚、师生关系融洽。
欢迎对科研有热情、有理想的同学加入,攻读硕博连读学位!实验室长期诚聘遗传学、生物化学与分子生物学等方向的博士后加入!
写给所有愿意加入本课题组的同学们:人生很短,余生很长,我们都期待和志趣相同的人一起去做有意义的事。期待相遇这样的你:怀有家国天下,心存善良和感恩,充满自信与活力,拥有强烈的责任感、专注度和执行力。愿正在努力的你,不负韶华,未来可期。
研究生招收专业:生物化学与分子生物学(免疫与DNA损伤修复)、细胞生物学(细胞周期调控)、遗传学
代表性论文 (†共同第一作者,*共同通讯作用):
(1) Weiyi Bao, Weijia Zhang, Yongchi Huang, Yan Zhao, Cong Wu, Leilei Duan, Lili Wang*, Shunping Yan*. Protein kinase ATR inhibits E3 ubiquitin ligase CRL4PRL1 to stabilize ribonucleotide reductase in response to replication stress. Cell Reports, 2023, 42: 112685.
(2) Chen Yu, Longhui Hou, Yongchi Huang, Xiaoyu Cui, Shijun Xu, Lili Wang*, Shunping Yan*. The multi-BRCT domain protein DDRM2 promotes the recruitment of RAD51 to DNA damage sites to facilitate homologous recombination. New Phytologist, 2023, 238:1073-1084.
(3) Hanchen Chen†, Ting Pan†, Xueao Zheng, Yongchi Huang, Cong Wu, Tongbin Yang, Shan Gao, Lili Wang, Shunping Yan*. The ATR-WEE1 kinase module promotes SUPPRESSOR OF GAMMA RESPONSE 1 translation to activate replication stress responses.The Plant Cell, 2023, doi:10.1093/plcell/koad126.
(4) Cunliang Li†, Yuyu Guo†, Lili Wang, Shunping Yan*. The SMC5/6 complex recruits the PAF1 complex to facilitate DNA double-strand break repair in Arabidopsis. The EMBO Journal, 2023, 42: e112756.
(5) Ting Pan†, Shan Gao†, Xiaoyu Cui, Lili Wang, Shunping Yan*. APC/CCDC20 targets SCFFBL17 to activate replication stress responses in Arabidopsis. The Plant Cell. 2023, 35(2): 910-923.
(6) Xuanpeng Wang, Lili Wang, Yongchi Huang, Zhiping Deng, Cunliang Li, Jian Zhang, Mingxi Zheng, Shunping Yan*. A plant-specific module for homologous recombination repair. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (16): e2202970119.
(7) Tong Li; Shijun Xu; Chong Wu; Shunping Yan; Lili Wang*. Loss of an ABC transporter in Ara bidopsis thaliana confers hypersensitivity to the anti-cancer drug bleomycin, DNA Repair, 2021, 1 06(2021): 103174.
(8) Ting Pan, Qi Qin, Chubing Nong, Shan Gao, Lili Wang, Bingcheng Cai, Ming Zhang, Chong Wu, Hanchen Chen, Tong Li, Dan Xiong, Guoliang Li, Shui Wang, Shunping Yan. A novel WEE1 pathway for replication stress responses. Nature Plants, 2021, 7: 209-218.
(9) Lili Wang, Li Zhan, Yan Zhao, Yongchi Huang, Chong Wu, Ting Pan, Qi Qin, Yiren Xu, Zhiping Deng, Jing Li, Honghong Hu, Shaowu Xue, Shunping Yan*. The ATR-WEE1 kinase module inhibits the MAC complex to regulate replication stress response, Nucleic Acids Research, 2021, 49(3): 1411-1425.
(10) Lili Wang, Hanchen Chen, Chongyang Wang, Zhenjie Hu, Shunping Yan*, Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair, Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (16): E3837-E3845.
(11) Lili Wang, Changchun Yu, Shanglin Xu, Yingguo Zhu*, Wenchao Huang*, OsDi19-4 acts downstream of OsCDPK14 to positively regulate ABA response in rice, Plant, Cell & Environment, 2016, 39 (12): 2740-2753.
(12) Lili Wang, Changchun Yu, Cong Chen, Chunlan He, Yingguo Zhu*, Wenchao Huang*, Identification of rice Di19 family reveals OsDi19-4 involved in drought resistance, Plant Cell Reports, 2014, 33 (12):2047–2062.
科研项目:
1. 华中农业大学高层次人才启动经费,2021-2026,主持
2. 国家自然科学基金面上项目,2021-2024,主持
3. 国家自然科学基金青年项目,2019-2021,主持
4. 湖北省青年拔尖人才培养计划,2024-2026,主持
5. 武汉英才-优秀青年人才,2023-2024,主持
6. 国家重点研发计划子课题,2024-2027,主持
7. 农业生物育种国家科技重大专项子课题,2024-2025,主持
主讲课程:
植物生理学、植物学、高级植物学、写作与沟通
指导学生获奖情况:
1. 2022届王瑞宇获华中农业大学2022届优秀本科毕业论文;
2. 2019级徐辰鸣的大学生科技创新基金(SRF)项目,其结题验收为校级优秀;
3. 2022 级范陈承获 2024 年湖北省大学生生物实验技能竞赛——植物学实验项目一等奖;
4. 2022级博士生包伟怡获第五届全国植物逆境生物学研讨会优秀墙报二等奖(2023,陕西杨凌)、博士研究生国家奖学金、中国植物生理与分子生物学学会 2024 年先正达齐尔顿研究生奖学金、2024 全国植物生物学青年博士(后)学术论坛优秀报告等。