刘鑫,男,中共党员,陕西西安人。华中农业大学副研究员,博士生/硕士生导师。2009-2018年在西北农林科技大学本硕博连读,长期从事家畜克隆胚胎发育和基因工程育种的研究。2018年加入华中农业大学猪繁殖学研究团队,(1) 围绕克隆胚胎发育障碍问题,从卵母细胞、供体细胞、表观修饰等方面建立猪高效克隆技术;(2) 针对哺乳动物的早期胚胎发育,从转录组、表观组、代谢组等方面揭示精卵结合、基因组激活、谱系分化等重要事件的发生机制。近5年发表胚胎发育领域相关高水平论文6篇,授权专利3项,主持科研项目6项。欢迎对胚胎发育感兴趣的优秀学子联系!
👆 猪克隆胚胎在基因组激活阶段的表观障碍研究(Stem Cell Reports, 2021)
👆 组蛋白变体H2A.Z在早期胚胎发育中的功能研究(Advanced Science, 2022)
代表作:
(1) Liu X#, Zhang JJ#, Zhou JL, Bu GW, Zhu W, He HN, Sun QR, Yu ZS, Xiong WJ, Wang LY, Wu DY, Dou CL, Yu LT, Zhou K, Wang SK, Fan ZG, Wang TT, Hu RF, Hu TT, Zhang X, Miao YL*. Hierarchical accumulation of histone variant H2A.Z regulates transcriptional states and histone modifications in early mammalian embryos. Advanced Science (A刊), 2022.
(2) Bu GW#, Zhu W#, Liu X#, Zhang JJ, Yu LT, Zhou K, Wang SK, Li ZK, Fan ZG, Wang TT, Hu TT, Hu RF, Liu ZT, Wang T, Wu LH, Zhang X, Zhao SH, Miao YL*. Coordination of zygotic genome activation entry and exit by H3K4me3 and H3K27me3 in porcine early embryos. Genome Research (B刊), 2022.
(3) Zhu W#, Bu GW#, Hu RF#, Zhang JX#, Qiao LY#, Zhou K, Wang TT, Li Q, Zhang JJ, Wu LH, Xie YL, Hu TT, Yang SC, Guan JQ, Chu XY, Shi JJ, Zhang X, Lu FL*, Liu X*, Miao YL*. KLF4 facilitates chromatin accessibility remodeling in porcine early embryos. SCIENCE CHINA Life Sciences (C刊), 2023.
(4) Liu X#, Chen L#, Wang T#, Zhou JL, Li ZK, Bu GW, Zhang JJ, Yin SY, Wu DY, Dou CL, Xu T, He HN, Zhu W, Yu LT, Liu ZT, Zhang X, Chen ZX*, Miao YL*. TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos. Stem Cell Reports (C刊), 2021.
(5) Liu X#, Wang YZ, Gao YP, Su JM, Zhang JC, Xing XP, Zhou C, Yao KZ, An QL, Zhang Y*. H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming. Development (C刊), 2018.