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陶攀

博士生导师
硕士生导师
教师姓名:陶攀
教师拼音名称:taopan
电子邮箱:
所在单位:动物科学技术学院、动物医学院
学历:博士研究生毕业
办公地点:协同创新中心511
学位:博士学位
职称:教授
所属院系:动物科学技术学院、动物医学院
其他联系方式

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个人简介

陶攀,博士,教授,博士生导师,国家海外优秀青年基金获得者、入选湖北省“百人计划”和“楚天学者”。农业微生物资源发掘与利用全国重点实验室、湖北洪山实验室固定研究人员。长期从事重大人畜共患传染病的防治、噬菌体资源开发与利用等相关研究。相关研究成果发表在Sci AdvNat Commun、PNASAdv Drug Deliv Rev、PLoS PathogmBio、JVI等国际学术期刊,被Science等多家杂志和11家国际学术媒体报道。申请发明专利10项,授权5项(其中国际专利1项)。承担了国家自然科学基金面上项目、海外优青、国家重点研发子课题等多项国家级科研项目。

 

个人学术主页

1. Google scholarhttps://scholar.google.com/citations?user=BZ2BttcAAAAJ&hl=en

2. Orcidhttps://orcid.org/0000-0002-0082-2229

 

代表性论文

1.    Li M, Chen C, Wang X, Guo P, Feng H, Zhang X, Zhang W, Gu C, Zhu J, Wen G, Feng Y, Xiao L, Peng G, Rao V, Tao P. T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines. Antiviral Research. 2023, 217:105688.

2.    Wang S, Sun E, Liu Y, Yin B, Zhang X, Li M, Huang Q, Tan C, Qian P, Rao V, Tao P. Landscape of new nuclease-containing antiphage systems in E. coli and the counter-defense roles of bacteriophage T4 genome modifications. J. Virol. 2023, doi: 10.1128/jvi.00599-23

3.    Zhu J, Batra H, Mahalingam M, Ananthaswamy N, Tao P, Wu X, Guo W, Fokine A, Rao V. Design of bacteriophage T4-based artificial viral vectors for human genome remodeling. Nat Commun. 2023, 14:2928.

4.    Wang Y, Guan Z, Wang C, Nie Y, Chen Y, Qian Z, Cui Y, Xu H, Wang Q, Zhao F, Zhang D, Tao P, Sun M, Yin P, Jin S, Wu Shan, Zou T. Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism. Nat Microbiol. 2022. 7(9):1480-1489

5.    Li M, Guo P, Chen C, Feng H, Zhang W, Gu C, We G, Rao VB, Tao P. Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development. Front Immunol. 2021. 12:745625. doi: 10.3389/fimmu.2021.745625

6.    Dong J, Chen C, Liu Y, Zhu J, Li M, Rao VB, Tao P. Engineering T4 bacteriophage for in vivo display by type V CRISPR-Cas genome editing. ACS Synth Biol. 2021. 10(10):2639-2648. doi: 10.1021/acssynbio.1c00251

7.    Wu X, Zhu J, Tao P, Rao VB. Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair. mBio. 2021. 12 (3), e01361-21

8.    Fang Q, Tang WC, Tao P, Mahalingam M, Fokine A, Rossmann MG, Rao VB. Structural morphing in a symmetry-mismatched viral vertex. Nat Commun. 2020,11(1):1713.

9.    Liu Y, Dai L, Dong J, Chen C, Zhu J, Rao VB, Tao P. Covalent modifications of bacteriophage genome confer a degree of resistance to bacterial CRISPR systems. J. Virol. 2020, 9; 94(23): e01630-20.

10.  Chen Y, Yang L, Yang D, Song J, Wang Can, Sun E, Gu C, Chen H, Tong Y, Tao P, Wu B. Specific Integration of Temperate Phage Decreases the Pathogenicity of Host Bacteria. Front. Cell. Infect. Microbiol. 2020, 10:14.

11.  Tao P, Zhu J, Mahalingam M, Batra H, Rao VB. Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases. Adv Drug Deliv Rev. 2019; 145:57-72.

12.  Zhu J, Tao P, Mahalingam M, Sha J, Kilgore P, Chopra AK, Rao V. A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells. Sci Adv. 2019, 5(8): eaax0064.

13.  Chen Y, Batra H, Dong J, Chen C, Rao VB, Tao P. Genetic Engineering of Bacteriophages against Infectious Diseases. Front Microbiol. 2019; 10:954.

14.  Tao P, Mahalingam M, Zhu J, Moayeri M, Sha J, Lawrence WS, Leppla SH, Chopra AK, Rao VB. A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague. mBio. 2018; 9(5). pii: e01926-18

15.  Tao P, Wu X, Rao V. Unexpected evolutionary benefit to phages imparted by bacterial CRISPR-Cas9. Sci Adv. 2018; 4(2): eaar4134.  

16.  Tao P, Wu X, Tang W, Zhu J, Rao VB. Engineering of Bacteriophage T4 Genome Using CRISPR-Cas9. ACS Synth Biol. 2017. doi: 10.1021/acssynbio.7b00179.

17.  Tao P, Mahalingam M, Zhu J, Moayeri M, Kirtley ML, Fitts EC, Andersson JA, Lawrence WS, Leppla SH, Chopra AK, Rao VB. A Bivalent Anthrax–Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis. Front Immunol. 2017 8:687.

18.  Dai L, Li Z, Tao P. Evolutionary Analysis of Tembusu Virus: Evidence for the Emergence of a Dominant Genotype. Infect Genet Evol. 2015, 32: 124-19.

19.  Tao P, Mahalingam M, Marasa BS, Zhang Z, Chopra AK, Rao VB. In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine. PNAS. 2013, 110(15):5846-5851. 

20. Tao P, Mahalingam M, Kirtley ML, van Lier CJ, Sha J, Yeager LA, Chopra AK, Rao VB. Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines. PLoS Pathog. 2013, 9(7): e1003495. 


教育经历

[1] 2004.9——2009.6
武汉大学 > 博士 > 博士
[2] 2000.9——2004.6
华中农业大学 > 学士 > 学士

工作经历

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