Pan TAO, Ph.D

Professor, College of Veterinary Medicine, HZAU

Education & Working Experience

B.Sc., Huazhong Agricultural University, Wuhan, China

Ph.D., Wuhan University, Wuhan, China

Postdoc fellow, the Catholic University of America, Washington DC, USA

Research Assistant professor, the Catholic University of America, Washington DC, USA

Professor, Huazhong Agricultural University, Wuhan, China

Research Interest

1. Characterize the adaptive immune responses against animal pathogens.

2. New technologies for diagnose, prevention, therapy of animal infectious diseases.

3.The interaction of bacteriophages and their bacterial hosts. 

Personal Websites

1. Google scholar：https://scholar.google.com/citations?user=BZ2BttcAAAAJ&hl=en

2. Orcid：https://orcid.org/0000-0002-0082-2229

Selected Publications

1.    Li M, Chen C, Wang X, Guo P, Feng H, Zhang X, Zhang W, Gu C, Zhu J, Wen G, Feng Y, Xiao L, Peng G, Rao V, Tao P. T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines. Antiviral Research. 2023, 217:105688.

2.    Wang S, Sun E, Liu Y, Yin B, Zhang X, Li M, Huang Q, Tan C, Qian P, Rao V, Tao P. Landscape of new nuclease-containing antiphage systems in E. coli and the counter-defense roles of bacteriophage T4 genome modifications. J. Virol. 2023, doi: 10.1128/jvi.00599-23.

3.    Zhu J, Batra H, Mahalingam M, Ananthaswamy N, Tao P, Wu X, Guo W, Fokine A, Rao V. Design of bacteriophage T4-based artificial viral vectors for human genome remodeling. Nat Commun. 2023, 14:2928.

4.    Wang Y, Guan Z, Wang C, Nie Y, Chen Y, Qian Z, Cui Y, Xu H, Wang Q, Zhao F, Zhang D, Tao P, Sun M, Yin P, Jin S, Wu Shan, Zou T. Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism. Nat Microbiol. 2022. 7(9):1480-1489.

5.    Li M, Guo P, Chen C, Feng H, Zhang W, Gu C, We G, Rao VB, Tao P. Bacteriophage T4 Vaccine Platform for Next-generation Influenza Vaccine Development. Front Immunol. 2021. 12:745625. doi: 10.3389/fimmu.2021.745625.

6.    Dong J, Chen C, Liu Y, Zhu J, Li M, Rao VB, Tao P. Engineering T4 bacteriophage for in vivo display by type V CRISPR-Cas genome editing. ACS Synth Biol. 2021. 10(10):2639-2648. doi: 10.1021/acssynbio.1c00251.

7.    Wu X, Zhu J, Tao P, Rao VB. Bacteriophage T4 Escapes CRISPR Attack by Minihomology Recombination and Repair. mBio. 2021. 12 (3), e01361-21.

8.    Fang Q, Tang WC, Tao P, Mahalingam M, Fokine A, Rossmann MG, Rao VB. Structural morphing in a symmetry-mismatched viral vertex. Nat Commun. 2020,11(1):1713.

9.    Liu Y, Dai L, Dong J, Chen C, Zhu J, Rao VB, Tao P. Covalent modifications of bacteriophage genome confer a degree of resistance to bacterial CRISPR systems. J. Virol. 2020, 9; 94(23): e01630-20.

10.  Chen Y, Yang L, Yang D, Song J, Wang Can, Sun E, Gu C, Chen H, Tong Y, Tao P, Wu B. Specific Integration of Temperate Phage Decreases the Pathogenicity of Host Bacteria. Front. Cell. Infect. Microbiol. 2020, 10:14.

11.  Tao P, Zhu J, Mahalingam M, Batra H, Rao VB. Bacteriophage T4 nanoparticles for vaccine delivery against infectious diseases. Adv Drug Deliv Rev. 2019; 145:57-72.

12.  Zhu J, Tao P, Mahalingam M, Sha J, Kilgore P, Chopra AK, Rao V. A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells. Sci Adv. 2019, 5(8): eaax0064.

13.  Chen Y, Batra H, Dong J, Chen C, Rao VB, Tao P. Genetic Engineering of Bacteriophages against Infectious Diseases. Front Microbiol. 2019; 10:954.

14.  Tao P, Mahalingam M, Zhu J, Moayeri M, Sha J, Lawrence WS, Leppla SH, Chopra AK, Rao VB. A Bacteriophage T4 Nanoparticle-Based Dual Vaccine against Anthrax and Plague. mBio. 2018; 9(5). pii: e01926-18. 

15.  Tao P, Wu X, Rao V. Unexpected evolutionary benefit to phages imparted by bacterial CRISPR-Cas9. Sci Adv. 2018; 4(2): eaar4134.  

16.  Tao P, Wu X, Tang W, Zhu J, Rao VB. Engineering of Bacteriophage T4 Genome Using CRISPR-Cas9. ACS Synth Biol. 2017. doi: 10.1021/acssynbio.7b00179.

17.  Tao P, Mahalingam M, Zhu J, Moayeri M, Kirtley ML, Fitts EC, Andersson JA, Lawrence WS, Leppla SH, Chopra AK, Rao VB. A Bivalent Anthrax–Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis. Front Immunol. 2017 8:687.

18.  Dai L, Li Z, Tao P. Evolutionary Analysis of Tembusu Virus: Evidence for the Emergence of a Dominant Genotype. Infect Genet Evol. 2015, 32: 124-19.

19.  Tao P, Mahalingam M, Marasa BS, Zhang Z, Chopra AK, Rao VB. In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine. PNAS. 2013, 110(15):5846-5851. 

20. Tao P, Mahalingam M, Kirtley ML, van Lier CJ, Sha J, Yeager LA, Chopra AK, Rao VB. Mutated and bacteriophage T4 nanoparticle arrayed F1-V immunogens from Yersinia pestis as next generation plague vaccines. PLoS Pathog. 2013, 9(7): e1003495.