苗义良
博士生导师
硕士生导师
教师姓名：苗义良
教师拼音名称：Miao Yiliang
职务：副院长
职称：教授
学历：博士研究生毕业
学位：博士学位
办公地点：第四综合楼E614
电子邮箱：
毕业院校：中国科学院动物研究所
所属院系：动物科学技术学院、动物医学院
所在单位：动物科学技术学院、动物医学院
其他联系方式
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科学研究
研究领域
1) 动物早期胚胎发育与体细胞重编程机制；
2) 胚胎干细胞多能性维持与分化机制调控；
3) 基因编辑与动物模型创制；
4)动物繁殖新技术研发 。
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论文成果
- Wu L#, Su P#, Li D, Zhou K, Song W, Shi J, Wang Q, Huang Q, Hu S, Zhang X, Liu X, Zhou J*, Miao YL*. LEUTX and OTX2 orchestrate totipotency-to-pluripotency transitions and heterogeneity in pEPSCs. Cell Reports. 2025 Oct 28;44(10):116385..
- He H#, Zhang Q#, Fan Z#, Duan H, Wang Y, Luo B, Li Q, Liu J, Li D, Fang S, Zhang X, Wang J*, Miao YL*, Zhou J*. Autophagy dictates PHGDH-mediated serine metabolism in a timely manner to support oocyte development. Autophagy. 2025 Sep 5:1-20.
- Su P#, Wu L#, Li D, Song W, Tao D, Liu L, Wang Q, Gao M, Xu T, Liu X, Xie S, Zhang X, Zhou J*, Miao YL*. CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells. Advanced Science (Weinh). 2025 Sep;12(34):e09495..
- Zhang J#, Sun Q#, Liu L, Yang S, Zhang X, Miao YL*, Liu X*. Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency. EMBO Journal. 2025 Jan;44(2):437-456..
- Qin W#, Wang Y#, Duan H, Li Q, Tao D, Su P, Wu L, Li D, Xu T, Xie S, Zhang X, Zhou J*, Miao YL*. PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells. Fundamental Research. 2024 Nov 12;5(4):1556-1569..
著作成果
- ,Su P, Miao YL*. A Genome-Wide CRISPR/Cas9 Screen Identifies Regulatory Genes for Stem Cell Aging. Methods Mol Biol. 2024 Dec 21. doi: 10.1007/7651_2024_566..2025
- ,Wu DY, Zhang X, Miao YL*. Reprogramming of Aged Cells into Pluripotent Stem Cells by Nuclear Transfer. Methods Mol Biol. 2019;2045:271-281..2021
