李晓雪

男，1984年5月出生，教授，博士生导师。

先后在华中农业大学和瑞士洛桑联邦理工大学求学工作，主要研究昆虫免疫学，在昆虫先天免疫和肠道干细胞领域开展了系统性工作，取得昆虫系统稳态和组织间通讯研究关键性突破，首次提出马氏管是昆虫体内重要的免疫耐受参与者，可以维持活性氧的平衡，避免免疫反应中的组织损伤，通过促进肠道干细胞的分化增殖调控肠道稳态。

研究方向：

实验室目前以以重大果树害虫橘小实蝇和模式生物黑腹果蝇为主要研究对象，聚焦其环境适应性机制，围绕生物体如何应对逆境胁迫和病菌侵染，深入研究免疫胁迫和环境胁迫条件下昆虫适应性的生理机制。

科研项目：

1. 华中农业大学人才引进项目, 项目年限：2021-2025，200万元，主持

2. 国家自然科学基金委员会, 国际(地区)合作与交流项目, 32220103009, 肠道共生菌调控橘小实蝇生殖 的分子机制研究, 2023-01-01 至 2027-12-31, 231万元, 在研, 参与

3. 科技部, 重点研发计划项目子课题, 2021YFC2600405-4, 橘小实蝇、南亚果实蝇绿色综合防控技术研 发及应用示范, 2021-12 至 2024-11, 119万元, 主持

4.  "武汉英才"（优秀青年人才），2022-2024，20万元，主持

5.  湖北省高层次人才项目

发表论文：

1.   Yanning Liu, Rengang Luo, Bruno Lemaitre, Hongyu Zhang*, Xiaoxue Li* (2024) Bacterial-tyramine-induced renal-gut countercurrent flow regulates gut immune response by promoting ROS accumulation and gut peristalsis in the fly Bactrocera dorsalis. Biorxiv, doi: https://doi.org/10.1101/2024.03.22.586092

2.   Zhonggeng Liu, Hongyu Zhang, Bruno Lemaitre*, Xiaoxue Li* (2024) Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow. Cell Reports. Accepted.

3.   Jian Gu, Ping Zhang, Zhichao Yao, Xiaoxue Li *, Hongyu Zhang * (2023) BdNub is essential for maintaining gut immunity and microbiome homeostasis in Bactrocera dorsalis. Insects. 14 (2), 178

4.   Xie J, Chen H, Zheng W, Cai Z, Li X*, Zhang H* (2022) miR-275/305 cluster is essential for maintaining energy metabolic homeostasis by the insulin signaling pathway in Bactrocera dorsalis. PLoS Genet 18(10): e1010418. https://doi.org/10.1371/journal.pgen.10104182.  

5.   Xiaoxue Li*; Bruno Lemaitre*; (2021) Autophagy as a gatekeeper of intestinal homeostasis, Developmental Cell,  56(1): 5-6. 

6.   Xiaoxue LI*; Samuel Rommelaere; Shu Kondo; Bruno Lemaitre*; (2020) Renal purge of hemolymphatic lipids prevents the accumulation of ROS-induced inflammatory oxidized lipids and protects Drosophila from tissue damage, Immunity, 2020, 52(2): 374-387. 

7.   Hao Chen, Hao Sun, Junfei Xie, Zhichao Yao, Wenping Zheng, Ziniu Li, Zhurong Deng, Xiaoxue Li, Hongyu Zhang, CRISPR/Cas9-induced Mutation of Sex Peptide Receptor Gene Bdspr Affects Ovary, Egg Laying, and Female Fecundity in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), Journal of Insect Science, Volume 23, Issue 1, January 2023, 2

8.   Chng, W.A., Koch, R., Li, X., Kondo, S., Nagoshi, E., and Lemaitre, B. (2017). Transforming Growth Factor β/Activin signaling in neurons increases susceptibility to starvation. PLoS ONE 12, e0187054.

9.   Dong, X., Li, X., Li, Q., Jia, H., and Zhang, H. (2017). The inducible blockage of RNAi reveals a role for polyunsaturated fatty acids in the regulation of dsRNA-endocytic capacity in Bactrocera dorsalis. Scientific Reports 7, 5584.

10.   Chakrabarti, S., Dudzic, J.P., Li, X., Collas, E.J., Boquete, J.-P., and Lemaitre, B. (2016). Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila. PLoS Genetics 12, e1006089.