赖雪雷，华中农业大学生命科学技术学院教授、博士生导师，作物遗传改良全国重点实验室及洪山实验室研究员。2013至2016年在欧洲同步辐射光源中心开展博士课题研究，获得荷兰格罗宁根大学生物化学与分子生物学博士学位。2016至2021年，先后在英国剑桥大学Sainsbury实验室和法国国家科学院从事博士后研究，聚焦植物生殖发育与环境互作。以第一或通讯作者身份（含共同）在Nature Communications、Molecular Plant、PNAS和Angewandte Chemie等国际学术期刊发表论文，为Molecular Plant、Current Opinion in Plant Biology等期刊撰写综述文章。以合作者身份在Nature、Nature Plants和Plant Cell等期刊发表论文。入选国家高层次青年人才项目，主持国家重点研发计划青年科学家项目、国家自然科学基金面上项目和湖北省自然科学基金杰出青年项目等。

课题组现隶属于作物遗传改良全国重点实验室--水稻团队--非生逆境亚团队（熊立仲主持）。目前主要以主粮作物水稻为研究对象，解析水稻感知环境与胁迫信号的遗传与分子基础，尤其是温度信号的调控，包括高温（>38°C）、低温（<10°C）和环境温度（20-32°C），为水稻的环境适应性遗传改良提供基因资源和理论基础。

关键词：水稻；逆境感知；温度；遗传改良

Xuelei Lai is a professor at the College of Life Science and Technology at Huazhong Agricultural University, as well as a researcher at the National Key Laboratory of Crop Genetic Improvement and Hubei Hongshan Laboratory in Wuhan, China. He earned his Ph.D. from the University of Groningen in the Netherlands in 2016. From 2016 to 2021, he conducted postdoctoral research at the University of Cambridge and the French National Centre for Scientific Research, focusing on plant temperature sensing and flower development.

Currently, Dr. Lai's laboratory investigates how rice (Oryza sativa) senses abiotic stress signals, with a particular emphasis on temperature stresses, including low, high, and high ambient temperatures. His goal is to develop climate-resilient rice varieties to address the challenges posed by a growing global population in the context of climate change.

Keywords: Rice, Abiotic stress sensing/signaling, Temperature, Genetic improvement

科研项目

科技部重点研发计划青年科学家项目，水稻生殖发育期耐高温机制和遗传改良，2024-01至2028-12，主持

科技部“中法科研伙伴交流计划”项目，一个水稻转录调控复合体的相分离介导的低温感应机制研究，2024-01至2025-12，主持

国家科技重大专项（原“科技创新2030-重大项目”），耐非生物逆境新基因挖掘与育种价值评价，2023-2025，子课题主持

湖北省自然科学基金重点项目，杰出青年，水稻高温感应机制和遗传改良，2023-10至2026-09，主持

国家自然科学基金委，面上项目，生物钟蛋白ELF3介导的温度感应机制研究，2023-01-01至2026-12-31，主持

华中农业大学海外高层次人才启动经费，水稻温度感知和遗传改良，2021-12至2026-11，主持

人才项目

2024年 中组部万人计划青年拔尖人才

2023年 湖北省杰青

2022年 湖北省“百人计划”（创新人才-省重点联系专家）

2021年 武汉英才计划（优秀青年人才）

2017年 国家优秀自费留学生奖（荷兰领区）

科研与学术工作经历

2021-现在  作物遗传改良全国重点实验室，固定研究人员

2021-现在  湖北洪山实验室，固定研究人员

2021-现在  华中农业大学，生命科学技术学院，教授

2017-2021  法国国家科学院，博士后

2016-2017  英国剑桥大学，博士后

Academic positions

2021-Present: Principal Investigator, National Key Laboratory of Crop Genetic Improvement, Wuhan, China

2021-Present: Principal Investigator, Hubei Hongshan Laboratory, Wuhan, China

2021-Present: Full Professor, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China  

2017-2021: Postdoc, The French National Centre for Scientific Research (Francois Parcy and Chloe Zubieta laboratory), Grenoble, France

2016-2017: Postdoc, The Sainsbury Laboratory, University of Cambridge (Philip A. Wigge), Cambridge, UK

教育经历

2013-2016   荷兰格罗宁根大学，生物化学与分子生物学，博士学位

2009-2012   吉林大学，食品科学与工程，硕士学位

2005-2009   长春工业大学，食品科学与工程，学士学位

Education

2013-2016: University of Groningen (Bauke W. Dijkstra laboratory), Groningen, The Netherlands, PhD in biochemistry and molecular biology

2009-2012: Jilin University, Changchun, Jilin, China, master’s in food science and technology

2005-2009: Changchun University of Technology, Changchun, Jilin, China, bachelor’s in food science and technology

代表性成果（*共一; #通讯作者）

Hu, D., Yao, Y., Lv, Y., You, J., Zhang, Y., Lv, Q., Li, J., Hutin, S., Xiong, H., Zubieta, C., Lai, X.#, Xiong, L.# (2024). The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice. Molecular Plant, 17(10):1520-1538.

Wang, H.*, Ye, T.*, Guo, Z., Yao, Y., Tu, H., Wang, P., Zhang, Y., Wang, Y., Li, X., Li, B., Xiong, H., Lai, X.#, Xiong, L.# (2024). A double-stranded RNA binding protein enhances drought resistance via protein phase separation in rice. Nature Communications, 15 (2514).

Lai, X.*, Vega-Leon, R.*, Hugouvieux, V.*#, Blanc-Mathieu, R. van der Wal, F., Lucas, J., Silva, C.S., Jourdain, A., Muino, J., Nanao, M.H., Immink, R., Kaufmann, K., Parcy, F., Smaczniak, C.#, Zubieta C.# (2021). The Intervening Domain Is Required For DNA-binding and Functional Identity of Plant MADS Transcription Factors. Nature Communications, 12 (4760).

Lai, X.*, Blanc-Mathieu, R.*, GrandVuillemin L., Huang, Y., Stigliani, A., Lucas, J., Thévenon, E., Loue-Manifel, J., Turchi, L., Daher, H., Brun-Hernandez, E., Vachon, G., Latrasse, D., Benhamed, M., Dumas, R., Zubieta, C., and Parcy, F.# (2021). The LEAFY floral regulator displays pioneer transcription factor properties. Molecular Plant, 14(5):829-837.

Lai, X.*, Stigliani, A.*, Lucas, J., Hugouvieux, V., Parcy, F.#, and Zubieta, C.# (2020). Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing. Nucleic Acids Research, 48 (17), 9637–9648.

Silva, C.S.*#, Nayak, A.*, Lai, X.*, Hutin, S.#, Hugouvieux, V., Jung, J.-H., López-Vidriero, I., Franco-Zorrilla, J.M., Panigrahi, K.C.S., Nanao, M.H., Wigge, P.A., and Zubieta, C.# (2020). Molecular mechanisms of Evening Complex activity in Arabidopsis. Proceedings of the National Academy of Sciences, 117 (12), 6901–6909.

Lai, X.*, Chahtane, H.*, Martin-Arevalillo, R., Zubieta, C., and Parcy, F.# (2020). Contrasted evolutionary trajectories of plant transcription factors. Current Opinion in Plant Biology, 54, 101–107.

Lai, X.#, Stigliani, A., Vachon, G., Carles, C., Smaczniak, C., Zubieta, C., Kaufmann, K., and Parcy, F.# (2019). Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants. Molecular Plant, 12 (6), 743–763.

Lai, X., Wichers, H.J., Soler‐Lopez, M.#, and Dijkstra, B.W.# (2017). Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angewandte Chemie International Edition, 56 (33), 9812–9815.

其它研究成果

Zubieta, C., Hutin, S., Jung, J., and Lai, X.# (2024). Phosphorylation of PHYB by GSK3S, a key mechanism that brings temperature sensors together. New Phytologist, nph.20232.

Thoris, K., Correa Marrero, M., Fiers, M., Lai, X., Zahn, I.E., Jiang, X., Mekken, M., Busscher, S., Jansma, S., Nanao, M., de Ridder, D., van Dijk, A.D.J., Angenent, G.C., Immink, R.G.H., Zubieta, C., Bemer, M. (2024). Uncoupling FRUITFULL’s functions through modification of a protein motif identified by co-ortholog analysis. Nucleic Acids Research, gkae963.

Hugouvieux, V., Blanc-Mathieu, R., Janeau, A., Paul, M., Lucas, J., Xu, X., Ye, H., Lai, X., LeHir, S., Guillotin, A., Galien, A., Yan, W., Nanao, M., Kaufmann, K., Parcy, F., Zubieta, C.# (2024). SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development. Plant Cell, koae151.

Li, W.*, Yan, J.*, Zhang, Y., Zhang, F., Guan, Z., Yao, Y., Chang, Y., Tu, H., Li, X., Wang, H., Xiong, H., Lai, X., Yin, P., Xiong, L# (2023). Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice. Nature Plants, 9(7), 1130-1142.

Jung, J.-H.*, Barbosa, A.D.*, Hutin, S.*, Kumita, J.R., Gao, M., Derwort, D., Silva, C.S., Lai, X., Pierre, E., Geng, F., Kim, S.B., Baek, S., Zubieta, C., Jaeger, K.E., and Wigge, P.A.# (2020). A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature, 585, 256–260.

Ezer, D., Jung, J.-H., Lan, H., Biswas, S., Gregoire, L., Box, M.S., Charoensawan, V., Cortijo, S., Lai, X., Stöckle, D., Zubieta, C., Jaeger, K.E., and Wigge, P.A.# (2017). The evening complex coordinates environmental and endogenous signals in Arabidopsis. Nature Plants, 3, 17087.

招聘

实验室依托作物遗传改良全国重点实验室和湖北洪山实验室，招收博士后1-2名（常年有效）、博士研究生1-2名/年和硕士研究生2-4名/年。欢迎对“气候变化”、“温度感应”、“作物遗传改良”和“植物环境适应性”等关键词感兴趣的有志之士加入。

Come and join us

We are part of the National Key Laboratory of Crop Genetic Improvement and the newly established Hubei Hongshan Laboratory, which are both among the most advanced and promising plant and crop research centers in China. Our lab is recruiting postdoc researchers (1-2), PhD students (1-2 per year) and master students (2-4 per year). We welcome motivated researchers and students who are interested in key words, e.g., climate change, temperature sensing, crop genetic improvement, plant adaptation to environmental stresses, to join us. We provide competitive salary, housing and state-of-the-art research facilities.

Contact

Email: xuelei_lai@mail.hzau.edu.cn

X: https://twitter.com/Xuelei_Lai

Google scholar: https://scholar.google.co.uk/citations?user=3NaY5wUAAAAJ&hl=en

ResearchGate: https://www.researchgate.net/profile/Xu

Address

B612, Rice temperature sensing group,

National Key Laboratory of Crop Genetic Improvement,

Hubei Hongshan Laboratory, Huazhong Agricultural University,

No.1, Shizishan Street, Hongshan District, Wuhan, Hubei Province, P.R.China