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赖雪雷

博士生导师
硕士生导师
教师姓名:赖雪雷
教师拼音名称:Lai Xuelei
电子邮箱:
所在单位:生命科学技术学院
学历:博士研究生毕业
办公地点:作物遗传改良全国重点实验室(第二综合楼)B612
学位:理学博士学位
职称:教授
在职信息:在职
毕业院校:荷兰格罗宁根大学
所属院系:生命科学技术学院
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个人简介

赖雪雷,华中农业大学生命科学技术学院教授、博士生导师,作物遗传改良全国重点实验室和湖北洪山实验室研究员。主持国家重点研发计划(青年科学家项目2023年)、科技部“中法科研伙伴交流计划”(2023年)、湖北省自然科学基金(杰出青年项目2023年)和国家自然科学基金(面上项目2022年)等项目。2016年博士毕业于荷兰格罗宁根大学(生物化学与分子生物学),2016年至2021年在英国剑桥大学和法国国家科学院从事博士后研究,聚焦植物温度感应和生殖发育以及两者的互作机制,研究成果发表在Nature CommunicationsMolecular PlantPNASNucleic Acids ResearchNature PlantsNature等国际知名期刊,受邀在Molecular PlantCurrent Opinion in Plant Biology等期刊撰写综述。

课题组隶属于作物遗传改良全国重点实验室--水稻团队--非生逆境亚团队(熊立仲),采用遗传学、生物化学、生物物理学和生物信息学等手段,解析水稻感知环境/胁迫信号的遗传和分子基础(特别是温度信号,包括高温、低温和升高的环境温度),旨在为水稻的环境适应性遗传改良提供重要的基因资源和理论基础。

 

Xuelei Lai is a professor and doctoral supervisor at the College of Life Science and Technology of Huazhong Agricultural University, and a researcher at the National Key Laboratory of Crop Genetic Improvement and Hubei Hongshan Laboratory, Wuhan, China. He graduated from the University of Groningen in the Netherlands with a Ph.D. in 2016. From 2016 to 2021, he was a postdoctoral researcher at the University of Cambridge and the French National Centre for Scientific Research, respectively. He worked on plant temperature sensing and flower development, and published paper in major journals such as Nature Communications, Molecular Plant and PNAS, and was invited to write review articles in journals such as Molecular Plant and Current Opinion in Plant Biology.

His lab currently works on how rice plants (Oryza sativa) sense abiotic stress signals (with a particular interest in temperature stresses, including low, high, and elevated ambient temperature), with a goal to breed climate-resilient rice varieties for the ever-increasing population in the context of global climate change. 

 

科研与学术工作经历:

2021-现在  作物遗传改良全国重点实验室,固定研究人员

2021-现在  湖北洪山实验室,固定研究人员

2021-现在  华中农业大学,生命科学技术学院,教授

2017-2021  法国国家科学院,博士后

2016-2017  英国剑桥大学,博士后

 

Academic positions:

2021-Present: Principal Investigator, National Key Laboratory of Crop Genetic Improvement, Wuhan, China

2021-Present: Principal Investigator, Hubei Hongshan Laboratory, Wuhan, China

2021-Present: Full Professor, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China  

2017-2021: Postdoc, The French National Centre for Scientific Research (Francois Parcy and Chloe Zubieta laboratory), Grenoble, France

2016-2017: Postdoc, The Sainsbury Laboratory, University of Cambridge (Philip A. Wigge), Cambridge, UK

 

教育经历:

2013-2016   荷兰格罗宁根大学,生物化学与分子生物学,博士学位

2009-2012   吉林大学,食品科学与工程,硕士学位

2005-2009   长春工业大学,食品科学与工程,学士学位

 

Education:

2013-2016: University of Groningen (Bauke W. Dijkstra laboratory), Groningen, The Netherlands, PhD in biochemistry and molecular biology

2009-2012: Jilin University, Changchun, Jilin, China, master’s in food science and technology

2005-2009: Changchun University of Technology, Changchun, Jilin, China, bachelor’s in food science and technology

 

代表性研究成果(*共一; #通讯作者):

Wang, H.*, Ye, T.*, Guo, Z., Yao, Y., Tu, H., Wang, P., Zhang, Y., Wang, Y., Li, X., Li, B., Xiong, H., Lai, X.#, Xiong, L.# (2024). A double-stranded RNA binding protein enhances drought resistance via protein phase separation in rice. Nature Communications, 15 (2514).

Lai, X.*, Vega-Leon, R.*, Hugouvieux, V.*#, Blanc-Mathieu, R. van der Wal, F., Lucas, J., Silva, C.S., Jourdain, A., Muino, J., Nanao, M.H., Immink, R., Kaufmann, K., Parcy, F., Smaczniak, C.#, Zubieta C.# (2021). The Intervening Domain Is Required For DNA-binding and Functional Identity of Plant MADS Transcription Factors. Nature Communications, 12 (4760).

Lai, X.*, Blanc-Mathieu, R.*, GrandVuillemin L., Huang, Y., Stigliani, A., Lucas, J., Thévenon, E., Loue-Manifel, J., Turchi, L., Daher, H., Brun-Hernandez, E., Vachon, G., Latrasse, D., Benhamed, M., Dumas, R., Zubieta, C., and Parcy, F.# (2021). The LEAFY floral regulator displays pioneer transcription factor properties. Molecular Plant, 14(5):829-837.

Lai, X.*, Stigliani, A.*, Lucas, J., Hugouvieux, V., Parcy, F.#, and Zubieta, C.# (2020). Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing. Nucleic Acids Research, 48 (17), 9637–9648.

Silva, C.S.*#, Nayak, A.*, Lai, X.*, Hutin, S.#, Hugouvieux, V., Jung, J.-H., López-Vidriero, I., Franco-Zorrilla, J.M., Panigrahi, K.C.S., Nanao, M.H., Wigge, P.A., and Zubieta, C.# (2020). Molecular mechanisms of Evening Complex activity in Arabidopsis. Proceedings of the National Academy of Sciences, 117 (12), 6901–6909.

Lai, X.*, Chahtane, H.*, Martin-Arevalillo, R., Zubieta, C., and Parcy, F.# (2020). Contrasted evolutionary trajectories of plant transcription factors. Current Opinion in Plant Biology, 54, 101–107.

Lai, X.#, Stigliani, A., Vachon, G., Carles, C., Smaczniak, C., Zubieta, C., Kaufmann, K., and Parcy, F.# (2019). Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants. Molecular Plant, 12 (6), 743–763.

Lai, X., Wichers, H.J., Soler‐Lopez, M.#, and Dijkstra, B.W.# (2017). Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angewandte Chemie International Edition, 56 (33), 9812–9815.

 

其它研究成果:

Hugouvieux, V., Blanc-Mathieu, R., Janeau, A., Paul, M., Lucas, J., Xu, X., Ye, H., Lai, X., LeHir, S., Guillotin, A., Galien, A., Yan, W., Nanao, M., Kaufmann, K., Parcy, F., Zubieta, C.# (2024). SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development. Plant Cell, koae151.

Li, W.*, Yan, J.*, Zhang, Y., Zhang, F., Guan, Z., Yao, Y., Chang, Y., Tu, H., Li, X., Wang, H., Xiong, H., Lai, X., Yin, P., Xiong, L#. (2023). Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice. Nature Plants, 9(7), 1130-1142.

Jung, J.-H.*, Barbosa, A.D.*, Hutin, S.*, Kumita, J.R., Gao, M., Derwort, D., Silva, C.S., Lai, X., Pierre, E., Geng, F., Kim, S.B., Baek, S., Zubieta, C., Jaeger, K.E., and Wigge, P.A.# (2020). A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature, 585, 256–260.

Ezer, D., Jung, J.-H., Lan, H., Biswas, S., Gregoire, L., Box, M.S., Charoensawan, V., Cortijo, S., Lai, X., Stöckle, D., Zubieta, C., Jaeger, K.E., and Wigge, P.A.# (2017). The evening complex coordinates environmental and endogenous signals in Arabidopsis. Nature Plants, 3, 17087.

 

招聘:

实验室依托作物遗传改良全国重点实验室和湖北洪山实验室,招收博士后1-2名(常年有效)、博士研究生1-2名/年和硕士研究生2-4名/年。欢迎对“气候变化”、“温度感应”、“作物遗传改良”和“植物环境适应性”等关键词感兴趣的有志之士加入。

 

Come and join us:

We are part of the National Key Laboratory of Crop Genetic Improvement and the newly established Hubei Hongshan Laboratory, which are both among the most advanced and promising plant and crop research centers in China. Our lab is recruiting postdoc researchers (1-2), PhD students (1-2 per year) and master students (2-4 per year). We welcome motivated researchers and students who are interested in key words, e.g., climate change, temperature sensing, crop genetic improvement, plant adaptation to environmental stresses, to join us. We provide competitive salary, housing and state-of-the-art research facilities.

 

Contacts:

Email: xuelei_lai@mail.hzau.edu.cn

Twitter: https://twitter.com/Xuelei_Lai

Google scholar: https://scholar.google.co.uk/citations?user=3NaY5wUAAAAJ&hl=en

ResearchGate: https://www.researchgate.net/profile/Xu

 

Address:

B612, Rice temperature sensing group,

National Key Laboratory of Crop Genetic Improvement,

Hubei Hongshan Laboratory, Huazhong Agricultural University,

No.1, Shizishan Street, Hongshan District, Wuhan, Hubei Province, P.R.China


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