黄小罗，华中农业大学信息学院教授、博士生导师；湖北洪山实验室研究员。博士毕业于德国慕尼黑大学，曾在英国 John Innes Centre  博士生交流访问。担任中国生物信息学会（筹）计算合成生物学专委会秘书长; Nature Computational Science、Nature Electronics、Advanced Science等期刊审稿人。 主持国家重点研发计划、国家自然科学基金等相关项目多项；以第一或通讯作者（含共同）在Nature Computational Science、Nature Plants、National Science Review、 Advanced Science、iMeta、 Small Methods、Chemical Engineering Journal 等杂志发表论文。申请专利 40 项，授权 25 项。

本课题组主要从事计算合成生物学方面的研究，聚焦通过人工智能和合成生物学技术结合，在人工 DNA 合成设计与蛋白表达优化、DNA 信息存储与计算、秸秆生物质高效利用等方面形成突破。

课题组同时招收具备干实验或湿实验背景的学生，欢迎有生物学、生物信息学、计算机科学、代谢工程、合成生物学、材料科学等相关学科背景的本科生、硕士/博士研究生加入。本课题组长期招聘博士后，欢迎通过邮件联系（huangxl@mail.hzau.edu.cn）。

Selected Publications

[1] Wen J^#, Zhang C^#, Chen X^#, Dai Z, Li M, Ma W, Yam C, Huang X*, Xiong C*, Mei H*. An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping. Communication Chemistry. 2025 ;8(1):144.

[2] Yu W^#, Zhang S^#, Zhao SJ, Chen L , Cao J, Ye H , Yan J, Zhao Q, Mo B, Wang Y, Jiao Y, Ma Y, Huang X*, Qian W*, and Dai J*.  Design of a synthetic Moss genome using GenoDesigner.  Nature Plants. 2024.

[3]  Huang X^#*, Hou Z^#, Qiang W^#, Wang H^#, Wang X, Chen X, Hu X, Dai J*, Li L*, Zhao G*. Towards next-generation DNA encryption via an expanded genetic system. National Science Review. 2024

[4] Hou Z^#, Qiang W^#, Wang X^#, Chen X, Hu X, Han X, Shen W, Zhang B, Xing P, Shi W, Dai J*, Huang X*, Zhao G*. “Cell Disk” DNA Storage System Capable of Random Reading and Rewriting". Advanced Science. 2024; e2305921.

[5] Huang X^#*, Cui J^#, Qiang W^#, Ye J^#, Wang Y, Xie X, Li Y, Dai J*. Storage-D: A user-friendly platform that enables practical and personalized DNA data storage. iMeta. 2024.

[6] Rasool A^#, Hong J^#, Hong Z, Li Y, Zou C, Chen H, Qu Q, Wang Y, Jiang Q*, Huang X* and Dai J*.  An Effective DNA-Based File Storage System for Practical Archiving and Retrieval of Medical MRI Data. Small Methods. 2024.

[7] Xu J^#, Wang Y^#，Chen X, Wang L, Zhou H, Mei H*, Chen S*, Huang X*. “Multi-layer” Encryption of Medical Data in DNA for Highly-Secure Storage. Materials Today Bio. 2024

[8] Xu J^#, Chun H*, Wang L,Mei H, Chen S*, Huang X*. DNA Microarray Chip: Its fabrication and  Cutting-edge Applications. Chemical Engineering Journal. 2024.

[9] Zhang H, Huang J , Wang X , Gao Z, Meng S , Li H, Zhou S, Wang S, Wang S, Yuan X, Yang X, Huang X*,  Qin Z*.  Embedding DNA-Based Natural Language  in Microbes for the Benefit  of Future Researchers. Digital Discovery. 2024.

[10]  Liu P, Xie S, Guo Q, Chen Y, Fan J, Kumar Nadda A, Huang X*, Chu X*. MpADC, an L-aspartate-α-decarboxylase, from Myzus persicae, that enables production of β-alanine with high yield by whole-cell enzymatic catalysis. Biotechnology for Biofuels and Bioproducts. 2023;16(1):157.

[11] Lu M, Wang Y, Qiang W, Cui J, Wang Y, Huang X*, Dai J*. Towards high-density storage of text and    images    into    DNA    by    the    “Xiao-Pang”    codec     system.    Science    China    Life    Sciences 2023 ;66(6):1447-1450.

[12] Ping Z^#, Chen S^#, Zhou G^#, Huang X^#, Zhu S, Zhang H, Lee H, Lan Z, Cui J, Chen T, Zhang, W, Yang H, Xu X*, Church G*, Shen Y*. Towards Practical and Robust DNA-based Data Archiving by Codec System Named ‘Yin-Yang’. Nature Computational Science. 2022 2, 234–242

[13] Ping Z^#，Ma D^#, Huang X^#, Chen S, Liu L, Zhu S*, Shen Y*; Carbon-based archiving: the current progress and future prospects of DNA-based data storage. Gigascience. 2019;8(6). pii: giz075. doi: 10.1093/gigascience/giz075. 0

[14] Tran NT^#, Huang X^#, Hong HJ, Bush MJ, Chandra G, Pinto D, Bibb MJ, Hutchings MI, Mascher T, Buttner MJ*. Defining the regulon of genes controlled by σE , a key regulator of the cell envelope stress response in Streptomyces coelicolor. Molecular Microbiology 2019 ;112(2):461-481. doi: 10.1111/mmi.14250. 

[15] Huang X^#, Pinto D^#, Fritz G, Mascher T*. 2015. Environmental sensing in Actinobateria: A comprehensive survey on the signaling capacity of this phylum. Journal of Bacteriology: JB. 00176-00115.  

Selected Patents

[1] “一种富含GC或AT的基因合成方法”. CN201610707981.2 (授权）第一发明人

[2] “一种改造的质粒复制子及其应用”；CN201710423493.3 (授权） 第一发明人

[3]  一种基于免疫算法的密码子优化方法CN201710611752.5 (授权）第四发明人

[4] “一种序列复杂基因的合成方法” CN201610920370.6 (授权）第一发明人

[5] “用于核酸合成的微流控芯片”；专利申请号: CN201880068740.5（授权）第三发明人

[6] “编码/解码方法、编码/解码器和存储方法、装置” CN201880068914.8（授权）第一发明人

[7] 存有数据信息的DNA序列的处理方法及装置； CN202011137220.0 （授权）第一发明人

[8] 一种生物芯片及其制备方法与应用; CN201980082590.8 （授权）第九发明人

[9] 核酸合成装置和纯化装置、其用途及核酸合成方法和纯化方法. CN201880099717.2 （授权）第二发明人

[10] 用于核酸合成的微流控芯片. CN201880068740.5 （授权）第三发明人