黄琦
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Scientific Research
Our group focuses on zoonotic and animal pathogenic bacteria such as Streptococcus suis and pathogenic Escherichia coli. Our research interests include the mechanism of pathogenesis of bacterial pathogens, molecular epidemiology, bacterial infection diagnosis, and novel antibacterial drugs and vaccines development.
(1) Mechanisms of pathogenesis: Our research is focused on important pathogenesis and pathogen-host interaction pathways such as the Bacterial Protein Secretion System, Metabolic Pathways, and Regulation of Virulence Gene Expression. We also develop techniques including transposon insertion sequencing technology (TraDis), CRISPR, CRISPRi, and other technologies to identify new virulence factors and pathogenic mechanisms.
(2) Molecular Epidemiology: Our study utilizes methods such as microbiology, Whole Genome Sequencing, and bioinformatics to elucidate the transmission patterns and cross species transmission mechanisms of important animal pathogens and foodborne pathogens, and reveal the contamination patterns of foodborne pathogens in livestock and poultry slaughter, processing, and sales.
(3) Rapid diagnosis technology and products development: We develop diagnostic methods for animal bacterial infectious diseases, and develop rapid detection methods including LAMP, RPA etc for on-farm infection diagnosis.
(4) Development of new antibacterial drugs, vaccines, nanoantibodies: We perform antimicrobial compounds screening, vaccines design , and nanobodies development.
- Zou G, Matuszewska M, Jia M, Zhou J, Ba X, Duan J, Zhang C, Zhao J, Tao M, Fan J, Zhang X, Jin W, Cui T, Zeng X, Jia M, Qian X, Huang C, Zhuo W, Yao Z, Zhang L, Li S, Li L, Huang Q, Wu B, Chen H, Tucker AW, Grant AJ, Holmes MA*, Zhou R*. A Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations. Adv Sci (Weinh). 2021 Dec 11:e2103388. doi: 10.1002/advs.202103388..
- Tang H, Zhang Q, Han W, Wang Z, Pang S, Zhu H, Tan K, Liu X, Langford PR, Huang Q, Zhou R, Li L*. Identification of FtpA, a Dps-like protein involved in anti-oxidative stress and virulence in Actinobacillus pleuropneumoniae. J Bacteriol. 2021 Nov 22:JB0032621. Doi: 10.1128/JB.00326-21..
- Xu Z, Chen X, Tan W, Cui H, Zhu Z, Yang C, Huang Q, Meng X*, Li S*. Prevalence and Antimicrobial Resistance of Salmonella and Staphylococcus aureus in Fattening Pigs in Hubei Province, China. Microb Drug Resist. 2021 Apr 29. doi: 10.1089/mdr.2020.0585..
- Huang J, Yang X, Wang A, Huang C, Tang H, Zhang Q, Fang Q, Yu Z, Liu X, Huang Q, Zhou R*, Li L*. Pigs Overexpressing Porcine β-Defensin 2 Display Increased Resilience to Glaesserella parasuis Infection. Antibiotics (Basel). 2020 Dec 14;9(12):903. Doi: 10.3390/antibiotics9120903..
- Li L, Chen Z, Bei W, Su Z, Huang Q, Zhang L, Chen H, Zhou R*. Catecholamines promote Actinobacillus pleuropneumoniae growth by regulating iron metabolism. PLoS One. 2015 Apr 7;10(4):e0121887. doi: 10.1371/journal.pone.0121887..
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