周少立，华中农业大学生命科学技术学院教授、博士生导师，作物遗传改良全国重点实验室和湖北洪山实验室研究员。国家级青年人才项目获得者，入选湖北省及武汉市人才计划。

2017年博士毕业于华中农业大学（生物化学与分子生物学），分别于2017年-2019年和2019-2023年在作物遗传改良全国重点实验室及英国John Innes Centre研究所从事博士后研究，聚焦水稻生殖发育表观遗传学方向，研究成果发表在Nature、Nature Plants、Molecular Plant、Plant Cell等国际期刊。

先后主持博士后创新人才支持计划、Marie Skłodowska-Curie Action grant（欧盟玛丽居里学者）、自然科学青年基金、湖北洪山实验室高层次人才启动经费等项目。入选国家高层次青年人才项目、湖北省创新人才、武汉英才等人才项目。

课题组隶属于作物遗传改良全国重点实验室--水稻团队，实验室主要以水稻为研究对象，聚焦生殖发育、受精、受精后发育、环境应答表观遗传学等分子机理研究，旨在为人们更好地理解作物生殖发育过程中的分子调控机理提供帮助，并服务于水稻分子育种改良。

本室长期招收具有科研热情、潜力的硕博士研究生，热烈欢迎博士后申请。激扬梦想，追求卓越！

Shaoli Zhou, professor and doctoral supervisor at the College of Life Science and Technology, Huazhong Agricultural University (HZAU), conducts research at the National Key Laboratory of Crop Genetic Improvement and Hubei Hongshan Laboratory. He was awarded by the National-level Young Talent Program and selected for the Talent Programs of Hubei province and Wuhan.  

He obtained his PhD degree from HAZU in 2017 and subsequently served as a post-doctoral researcher at the National Key Laboratory of Crop Genetic Improvement (China) from 2017 to 2019, and at John Innes Centre (UK) from 2019 to 2023. His interest primarily revolves around the epigenetic regulatory mechanism of rice reproductive development. He has published research findings in prestigious international journals such as Nature, Nature Plants, Molecular Plant and Plant Cell. 

Additionally, Shaoli Zhou heads and presides over several grants including the Postdoctoral Innovation Talent Support Program grant, Marie Skłodowska-Curie Action grant, Science Foundation for Youths, High-level Talent Start-up Funding and Other Projects. He was selected for the National High-Level Young Talents Program, Hubei Innovative Talents, and Wuhan Elite Talents.

The research group is affiliated with the National Key Laboratory of Crop Genetic Improvement - Rice Team, which focuses on molecular mechanism research in reproductive development, fertilization, post-fertilization development, environmental response epigenetics, and other areas related to rice as the research object. Its goal is to provide a better understanding of the molecular regulatory mechanisms involved in crop reproductive development and to serve the molecular breeding and improvement of rice.

Our lab is always open to recruiting enthusiastic and promising master and doctoral students with a passion for research, as well as welcoming applications from postdoctoral candidates. Let’s inspire dreams and pursue excellence together!

代表性研究成果

(1) Shaoli Zhou*; Xue Li*; Qian Liu; Yu Zhao; Wei Jiang; Anqi Wu; Dao-Xiu Zhou ; DNA demethylases remodel DNA methylation in rice gametes and zygote and are required for reproduction, Molecular Plant, 2021, 14(9): 1569-1583

(2) Shaoli Zhou; Wei Jiang; Yu Zhao; Dao-Xiu Zhou; Single-cell three-dimensional genome structures of rice gametes and unicellular zygotes, Nature Plants, 2019, 5(8): 795-800

(3) Toby Buttress*; Shengbo He*; Liang Wang*; Shaoli Zhou*; Gerhard Saalbach; Martin Vickers; Guohong Li; Pilong Li; Xiaoqi Feng ; Histone H2B.8 compacts flowering plant sperm through chromatin phase separation, Nature, 2022, 611(7936): 614-622

(4) Shaoli Zhou; Wei Jiang; Fei Long; Saifeng Cheng; Wenjing Yang; Yu Zhao; Dao-Xiu Zhou ; Rice homeodomain protein WOX11 recruits a histone acetyltransferase complex to establish programs of cell proliferation of crown root meristem, The Plant Cell, 2017, 29(5): 1088-1104

(5) Xiaoyun Liu*; Shaoli Zhou*; Wentao Wang; Yiran Ye; Yu Zhao; Qiutao Xu; Chao Zhou; Feng Tan; Saifeng Cheng; Dao-Xiu Zhou ; Regulation of histone methylation and reprogramming of gene expression in the rice inflorescence meristem, The Plant Cell, 2015, 27(5): 1428-1444

(6) Shaoli Zhou*; Xiaoyun Liu*; Chao Zhou*; Qiangwei Zhou; Yu Zhao; Guoliang Li; Dao-Xiu Zhou; Cooperation between the H3K27me3 chromatin mark and non-CG methylation in epigenetic regulation, Plant Physiology, 2016, 172(2): 1131-1141

(7) Wei Jiang*; Shaoli Zhou*; Qian Zhang; Huazhi Song; Dao-Xiu Zhou; Yu Zhao ; Transcriptional regulatory network of WOX11 is involved in the control of crown root development, cytokinin signals, and redox in rice, Journal of Experimental Botany, 2017, 68(11): 2787-2798

其它研究成果：

(1) Qian Liu*; Xuan Ma*; Xue Li; Xinran Zhang; Shaoli Zhou; Lizhong Xiong; Yu Zhao; Dao-Xiu Zhou; Paternal DNA methylation is remodelled to maternal levels in rice zygote, Nature Communications, 2023, 14(1)  

(2) Wei Jiang; Shaoli Zhou; Honglin Huang; Huazhi Song; Qinglu Zhang; Yu Zhao ; MERISTEM ACTIVITYLESS (MAL) is involved in root development through maintenance of meristem size in rice, Plant Molecular Biology, 2020, 104(4-5): 499-511 

(3) Yue Lu; Feng Tan; Yu Zhao; Shaoli Zhou; Xiangsong Chen; Yongfeng Hu; Dao-Xiu Zhou ; A Chromodomain-Helicase-DNA-Binding factor functions in chromatin modification and gene regulation, Plant Physiology, 2020, 183(3): 1035-1046  

(4) Feng Tan*; Chao Zhou*; Qiangwei Zhou*; Shaoli Zhou; Wenjing Yang; Yu Zhao; Guoliang Li; Dao-Xiu Zhou ; Analysis of chromatin regulators reveals specific features of rice DNA methylation pathways, Plant Physiology, 2016, 171(3): 2041-2054  

(5) Yu Zhao*; Saifeng Cheng*; Yaling Song; Yulan Huang; Shaoli Zhou; Xiaoyun Liu; Dao-Xiu Zhou ; The interaction between rice ERF3 and WOX11 promotes crown root development by regulating gene expression involved in cytokinin signaling, The Plant Cell, 2015, 27(9): 2469-2483

(6) Tiantian Li; Xiangsong Chen; Xiaochao Zhong; Yu Zhao; Xiaoyun Liu; Shaoli Zhou; Saifeng Cheng; Dao-Xiu Zhou ; Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice, The Plant Cell, 2013, 25(11): 4725-4736