基本信息：

姓名：于晓                                         性别：女

民族：汉族                                         职称：教授

学位：农学博士                                   硕/博导：博导

开设课程：植物免疫学、微生物学、分子植物与微生物互作                            

研究方向：植物免疫稳态调控机制；有益微生物内生植物及促生诱抗机制

联系方式：xiaoyu@mail.hzau.edu.cn

个人简介：

于晓，教授，博士生导师。入选“国家海外高层次引进人才”，农业微生物资源发掘与利用全国重点实验室、湖北省洪山实验室固定研究员。实验室研究领域为植物与微生物互作，主要研究方向为植物免疫稳态调控机制、有益微生物与植物相互作用及其诱导抗病性的分子机理。先后主持国家海外高层次人才计划青年项目和国家自然科学基金等。相关研究成果发表在Cell、Molecular Plant、 New Phytologist、Current Biology、PNAS和Cell Reports等国际权威期刊杂志，并在Annual Review of Phytopathology撰写了植物先天免疫反应研究进展的综述文章。

本课题组长期招收博士后，有意者请e-mail联系。

教育背景：

2008.9至2013.6    博士 华中农业大学 植物病理学

2004.9至2008.6    学士 华中农业大学 植物保护

工作经历：

2019.12至今          华中农业大学  植物科学技术学院  教授

2018.5至2019.5     德州农工大学  植物病理学和微生物学系  助理研究科学家

2013.1至2018.4     德州农工大学  植物病理学和微生物学系  博士后

科研与人才项目

1. 农业微生物学国家重点实验室科研平台项目（省市双一流), 2023-2026，主持

2. 国家自然科学基金青年项目，2023-2026，主持

3. 华中农业大学自主科技创新基金优秀人才培育项目，2020-2023，主持

4. 国家海外高层次人才引进项目，2020-2023，主持

5. 国家重点研发计划，2024-2027，子课题负责人

6. 华中农业大学自主科技创新基金“要术开物计划”培育项目，2025-2027，参与

6. 国家农业重大科技项目，2023-2026年，参与

7. 中央高校优秀青年团队培育建设项目，2023-2024，参与

代表论文：

1.  Ying Zhang, Meng Tang, Yi Zhang, Qinglin Cheng, Lijiang Liu, Wei Chen, Jiatao Xie, Jiasen Cheng, Yanping Fu, Bo Li, Daohong Jiang*, Xiao Yu* (2025) An enhancer-promoter-transcription factor module orchestrates plant immune homeostasis by constraining camalexin biosynthesis. Molecular Plant, 18(1):95-113.

2. Xiao Yu, Yingpeng Xie, Dexian Luo, Hai Liu, Marcos V V de Oliveira, Peipei Qi, Sung-Il Kim, Fausto Andres Ortiz-Morea, Jun Liu, Yafei Chen, Sixue Chen, Bárbara Rodrigues, Bo Li, Shaowu Xue, Ping He*, Libo Shan* (2023) A phospho-switch constrains BTL2-mediated phytocytokine signaling in plant immunity. Cell, 186(11):2329-2344.e20. doi: 10.1016/j.cell.2023.04.027.

2. Ying Wang, Meng Tang, Ying Zhang, Mengling Huang, Lan Wei, Yang Lin, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Bo Li, Xiao Yu* (2023) Coordinated regulation of plant defense and autoimmunity by paired trihelix transcription factors ASR3/AITF1 in Arabidopsis. New Phytologist, 2023 Feb;237(3):914-929.

3.  Xiao Yu#, Guangyuan Xu#, Bo Li, Luciano de Souza Vespoli, Hai Liu, Wolfgang Moeder, Sixue Chen, Marcos V.V. de Oliveira, Suzane Ariadina de Souza, Wenyong Shao, Barbara Rodrigues, Yi Ma, Shweta Chhajed, Shaowu Xue, Gerald A. Berkowitz, Keiko Yoshioka, Ping He* and Libo Shan* (2019) The receptor kinases BAK1/SERK4 regulate Ca2+ channel homeostasis in controlling plant cell death. Current Biology, 29 (22): 3778-3790.

4. Xiao Yu, Bo Li, Geng-Jen Jang, Shan Jiang, Daohong Jiang, Jyan-Chyun Jang, Shu-Hsing Wu, Libo Shan and Ping He* (2019) Orchestration of Processing body dynamics and mRNA decay in Arabidopsis immunity. Cell Reports. 28:2194–2205.

5. Xiao Yu, Baomin Feng, Ping He and Libo Shan* (2017) From Chaos to Harmony: Responses and Signaling upon Microbial Pattern Recognition. Annu Rev Phytopathol. 55:109-137.

6. Xiao Yu#, Bo Li#, Yanping Fu, Jiatao Xie, Jiasen Cheng, Said A. Ghabrial, Guoqing Li, Xianhong Yi and Daohong Jiang* (2013) Extracellular transmission of a DNA mycovirus and its use as a natural fungicide. Proc Natl Acad Sci USA. 110(4): 1452-1457

7. Xiao Yu#, Bo Li#, Yanping Fu, Daohong Jiang*, Said A. Ghabrial, Guoqing Li, Youliang Peng, Jiatao Xie, Jiasen Cheng, Junbin Huang, and Xianhong Yi（2010）A geminivirus-related DNA mycovirus that confers hypovirulence to a plant pathogenic fungus. Proc Natl Acad Sci USA.107:8387-8392.

参与论文：

1. Peipei Qi, Dan Zhang, Ying Zhang, Wanting Zhu, Xinya Du, Xiaoshuang Ma, Chunfang Xiao, Yang Lin, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li* (2024) Ubiquitination and degradation of plant helper NLR by the Ralstonia solanacearum effector RipV2 overcome tomato bacterial wilt resistance. Cell Reports. 27;43(8):114596.

2.Xiaofan Liu#, Huihui Zhao#, Mingyun Yuan, Pengyue Li, Jiatao Xie, Yanping Fu, Bo Li, Xiao Yu, Tao Chen, Yang Lin, Weidong Chen, Daohong Jiang, Jiasen Cheng* (2024)An effector essential for virulence of necrotrophic fungi targets plant HIRs to inhibit host immunity. Nature Communication. 30;15(1):9391.

3.Ying Zhang, Meng Tang, Mengling Huang, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li* (2023) Dynamic enhancer transcription associates with reprogramming of immune genes during pattern triggered immunity in Arabidopsis. BMC Biology. 21;20(1):165.

1.  Mengling Huang#, Ying Zhang#, Ying Wang, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li* (2022) Active DNA demethylation regulates MAMP-triggered immune priming in Arabidopsis. J Genet Genomics. 2022, 49(8):796-809

2. Peipei Qi#, Mengling Huang#, Xuehan Hu#, Ying Zhang, Ying Wang, Pengyue Li, Shiyun Chen, Dan Zhang, Sen Cao, Wanting Zhu, Jiatao Xie, Jiasen Cheng, Yanping Fu, Daohong Jiang, Xiao Yu, Bo Li* (2022) A Ralstonia solanacearum effector targets TGA transcription factors to subvert salicylic acid signaling. The Plant Cell. koac015. doi: 10.1093/plcell/koac015.

3. Chunfang Xiao, Mengling Huang, Jianhua Gao, Zhen Wang, Denghong Zhang, Yuanxue Zhang, Lei Yan, Xiao Yu, Bo Li* and Yanfen Shen* (2020) Comparative proteomics of three Chinese potato cultivars to improve understanding of potato molecular response to late blight disease. BMC Genomics, 21, 880.

4. Jun Liu#, Yanyan Huang#, Liang Kong, Xiao Yu, Baomin Feng, Derui Liu, Baoyu Zhao, Giselle C Mendes, Peiguo Yuan, Dongdong Ge, Wen-Ming Wang, Elizabeth P B Fontes, Pingwei Li, Libo Shan and Ping He* (2020) The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding. Nat Plants, 6(9):1106-1115.

5. Xiyu Ma, Lucas A N Claus, Michelle E Leslie, Kai Tao, Zhiping Wu, Jun Liu, Xiao Yu, Bo Li, Jinggeng Zhou, Daniel V Savatin, Junmin Peng, Brett M Tyler, Antje Heese, Eugenia Russinova, Ping He* and Libo Shan* (2020) Ligand-induced monoubiquitination of BIK1 regulates plant immunity. Nature, 581(7807):199-203.

6. Bo Li#*, Marco Aurélio Ferreira#, Mengling Huang, Luiz Fernando Camargos, Xiao Yu, Ruan M Teixeira, Paola A Carpinetti, Giselle C Mendes, Bianca C Gouveia-Mageste, Chenglong Liu, Claudia S L Pontes, Otávio J B Brustolini, Laura G C Martins, Bruno P Melo, Christiane E M Duarte, Libo Shan, Ping He and Elizabeth P B Fontes* (2019) The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity. Nat Commun, 1;10(1):4996.

7. Marcos Oliveira#, Guangyuan Xu#, Bo Li#, Luciano Vespoli, Xiangzong Meng, Xin Chen, Xiao Yu, SuzaneAriádina de Souza, Aline C. Intorne, Abbey L. Babinat, Hisashi Koiwa, Gonçalo A. de Souza Filho, Libo Shan* and Ping He* (2016) Specific control of Arabidopsis BAK1/SERK4-regulated cell death by protein glycosylation. Nat Plants 2:15218.

8. Xiangzong Meng, Xin Chen, Hunggon Mang, Chenglong Liu, Xiao Yu, Xiquan Gao, Keiko U. Torii, Ping He* and Libo Shan* (2015) Differential Function of Arabidopsis SERK Family Receptor-like Kinases in Stomatal Patterning. Curr Biol 21; 25(18):2361-72.

9. Bo Li#, Shan Jiang#, Xiao Yu, Cheng Cheng, Sixue Chen, Yanbing Cheng, Joshua Yuan, Daohong Jiang, Ping He and Libo Shan* (2015) Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE 4 negatively regulates Arabidopsis immunity. The Plant Cell 27: 839-856.

10. Fangjun Li#, Cheng Cheng#, Fuhao Cui#, Marcos V.V. de Oliveira#, Xiao Yu, Xiangzong Meng, Aline C. Intorne, Kevin Babilonia, Maoying Li, Bo Li, Sixue Chen, Xianfeng Ma, Shunyuan Xiao, Yi Zheng, Zhangjun Fei, Richard P. Metz, Charles D. Johnson, Hisashi Koiwa, Wenxian Sun, Zhaohu Li, Gonçalo A. de Souza Filho, Libo Shan* and Ping He* (2014) Modulation of RNA Polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity. Cell Host Microbe 16(6): 2014 748-758.

11. Huiquan Liu, Yanping Fu, Bo Li, Xiao Yu, Jiatao Xie, Jiasen Cheng, Said A Ghabrial, Guoqing Li, Xianhong Yi and Daohong Jiang* (2011) Widespread Horizontal Gene Transfer from Circular Single-stranded DNA Viruses to Eukaryotic Genomes. BMC Evol Biol.11:276.

发明专利：

1. 于晓;李博;张亚迪;谢甲涛;程家森;付艳苹;姜道宏. 一种多肽在植物病害防控中的应用, 2024-10-12, 中国，202411427868X

2. 姜道宏;宁功臣;谢甲涛;付艳苹;程家森;李博;陈桃;于晓. 核盘菌弱毒菌株DT-8在玉米增产中的应用和玉米促生增产剂及其制备方法, 2024-1-22, 中国, CN2024100887964.4 

3. 李博;杜鑫雅;于晓;付艳苹;姜道宏;谢甲涛;程家森. 一种从青枯菌中筛选抗青枯病的胞外核酸酶的方法及遗传改良应用， 2024-04-26, 中国，ZL202211004364.8

4. 李博;曹森;于晓;姜道宏;付艳苹;程家森;谢甲涛. 番茄基因SlLyk4在调控作物对土传病害抗性中的应用, 2024-04-26, 中国，ZL202211374145.9

5. 李博；李朋岳；于晓；程家森；谢甲涛；付艳苹；姜道宏.SlRIK1基因及其蛋白在免疫调控番茄青枯病中的应用, 2024-06-07, 中国，CN202410733795.0