王鹏蔚,群众,园艺林学学院园艺系教授,入选国家青年人才项目。2003-2006年就读与英国布里斯托大学,获得医学生物化学学士学位;2006-2010年在英国牛津布鲁克斯大学Chris Hawes教授实验室获得植物细胞生物学博士学位;2011-2017年在英国杜伦大学Patrick Hussey教授实验室从事博士研究。以第一作者/通讯作者在Current Biology、Nature Communications 、Trends in Plant Science、New Phytologist等国际著名杂志上发表论文30余篇,编写英文专著一部。担任中国自然科学基金(NSFC)重点项目、面上项目、青年项目;英国生物技术与生物科学研究会(BBSRC)等科研项目通讯评审专家。现任中国侨联特聘专家委员会委员、中国植物学会-植物细胞生物学专业委员会委员、湖北省细胞生物学会理事会理事;New Phytologist副主编。
实验室主要从事植物细胞生物学与园艺基础生物学研究,研究对象包括柑橘、番茄、拟南芥,主要研究方向包括:植物内质网-细胞器互作网络;植物细胞骨架;自噬的发生与调控; 细胞器功能与果实品质调控等,先后主持有国家自然科学基金重大研究计划培育项目、集成项目、国际(地区)合作项目,面上项目等,相关课题如下:
1. 自然科学基金国际(地区)合作项目:植物内质网-线粒体互作的分子基础及其对线粒体降解的影响,2023-2026;
2. 自然科学基金重点研究计划集成项目:细胞器互作调控细胞自噬的机制和功能研究,2023-2025,(参与);
3. 自然科学基金重点研究计划培育项目:植物内质网-质膜连接点与VAP27蛋白所调控的细胞自噬机制对生物胁迫的响应,2019-2021;
4. 自然科学基金面上项目:植物SCAR/WAVE复合体与线粒体协同调节的自噬机制及其对柑橘果实品质的影响,2018-2021;
5. 华中农大校自主创新基金:细胞骨架与内膜系统协同建立的细胞极性机制对柑橘胚胎发生的影响,2018-2020;
6. 国家重点研发计划子课题:柑橘果实品质保持过程中亚细胞器功能及品质调控机制研究,2018-2022;
7. 国家重点研发计划子课题:细胞生命活动对柑橘营养吸收和品质形成的调控机制,2019-2022;
8. 国家留学基金委: 地区科研合作与高层次人才培养项目“内质网在植物防御反应的功能研究”,2020-2021
代表性论文(#共同一作;*通讯作者):
1. Wang P*, Duckney P, Gao E, Hussey PJ, Kriechbaumer V, Li C, Zang J, Zhang T (2023) Keep in contact: multiple roles of endoplasmic reticulum-membrane contact sites and the organelle interaction network in plants. New Phytologist. In press
2. Guo Y#, Bao Z#, Deng Y, Li Y, Wang P.* (2022) Protein subcellular localization and functional studies in horticultural research: problems, solutions, and new approaches. Horticulture Research. DOI: 10.1093/hr/uhac271.
3. Duckney P#, Li C#, Hussey P. J.*, and Wang P.* (2022) TraB, a novel plant ER-mitochondrial contact site protein functions as a mitophagy receptor in plants. Autophagy. DOI: 10.1080/15548627.2022.2151190.
4. Li C#, Duckney P#, Zhang T, Fu Y, Li X, Kroon J, Jaeger G, Cheng Y, Hussey P. J.*, and Wang P.* (2022) TraB family proteins are components of ER-mitochondrial contact sites and regulate ER-mitochondrial interactions and mitophagy. Nature Communications. 13:5658. (Recommended by Faculty Opinion. Jiang L and Shen J, DOI: 10.3410/f.742339081.793596035)
5. Zang, J.#, Klemm, S.#, Pain, C., Duckney, P., Bao, Z., Stamm, G., Kriechbaumer, V., Bürstenbinder, K., Hussey, P. J.*, and Wang, P.* (2021). A Novel Plant Actin Microtubule Bridging Complex Regulates Cytoskeletal and ER Structure at Endoplasmic Reticulum Plasma Membrane Contact Sites. Current Biology, 31:1251-1260.
6. Gong, J.#, Zeng, Y.#, Meng, Q., Guan, Y., Li, C., Yang, H., Zhang, Y., Ampomah-Dwamena, C., Liu,P., Chen, C., Deng, X., Cheng, Y., and Wang,P.* (2021). Red light-induced citrus fruit colouration is attributable to increased carotenoid metabolism regulated by FcrNAC22. Journal of Experimental Botany. 72:6274-6290
7. Gong, J.#, Tian, Z.#, Qu, X., Meng, Q., Guan, Y., Liu, P., Chen, C., Deng, X., Guo, W., Cheng, Y., and Wang,P.* (2021). Illuminating the cells: transient transformation of citrus to study gene function and organelle activities related to fruit quality. Horticulture Research, 8:175
8. Wang, P.,* Gao, E., and Hussey PJ.* (2020) Autophagosome biogenesis in plants: an actin cytoskeleton perspective. Trends in Plant Science, 25:850-858.
9. Wang, P.#, Pleskot, R.#, Zang, J., Winkler, J., Wang, J., Yperman, K., Zhang, T., Wang, K., Gong, J., Guan, Y., et al. (2019). Plant AtEH/Pan1 proteins drive autophagosome formation at ER-PM contact sites with actin and endocytic machinery. Nature Communications. 10, 5132.
10. Wang, P., Hawkins, T.J. and Hussey P.J.* (2017) Connecting membranes to the actin cytoskeleton. Current Opinion in Plant Biology. 40: 71-76.
11. Wang, P. and Hussey, P.J.* (2017) NETWORKED 3B: a novel protein in the actin cytoskeleton-endoplasmic reticulum interaction. Journal of Experimental Botany 68(7): 1441-1450.
12. Wang P., Hawes C., and Hussey P.J.* (2017) Plant endoplasmic reticulum—plasma membrane contacts sites. Trends in Plant Science, 22(4): 289-297.
13. Wang, P., Richardson, C., Hawes, C. and Hussey, P.J* (2016). Arabidopsis NAP1 regulates the formation of autophagosomes. Current Biology, 26: 2060-2069. (Recommended by Hohfeld 2016 Curr Biol, R701-R718)
14. Wang, P., Hawkins, T.J., Richardson, C., Sparkes, I., Hawes, C. and Hussey, P.J.* (2016) Plant VAP proteins: domain characterization, intercellular localization, and role in plant development. New Phytologist, 210:1311-1326.
15. Knox, K.,# Wang, P.,# Kriechbaumer, K., Tilsner, J., Frigerio, L., Sparkes, I., Hawes, C. and Oparka, K.* (2015) Putting the squeeze on PDs- a role for RETICULONS in primary plasmodesmata formation. Plant Physiology, 168: 1563. (Co-first author)
16. Wang, P., Hawkins, T.J., Richardson, C., Cummins, I., Deeks, M.J., Sparkes, I., Hawes, C. and Hussey, P.J.* (2014) The plant cytoskeleton, NET3C, and VAP27 mediate the link between the plasma membrane and endoplasmic reticulum. Current Biology, 24, 1397
17. Wang, P., Hummel, E., Osterrieder, A., Meyer, A.J., Frigerio, L., Sparkes, I. and Hawes, C*. (2011) KMS1 and KMS2, two plant endoplasmic reticulum proteins involved in the early secretory pathway. The Plant Journal, 66, 613-628.
学术专著:
1. Wang, P., Hawes, C., Richardson, C., Hussey, P.J. (2018). Characterization of Proteins Localized to Plant ER-PM Contact Sites. In: Hawes, C., Kriechbaumer, V. (eds) The Plant Endoplasmic Reticulum. Methods in Molecular Biology, vol 1691. Humana Press, New York, NY. (Contributing Author)
2. Hussey, P.J. and Wang, P. (eds), The Plant Cytoskeleton: Methods and Protocols, Methods in Molecular Biology, vol. 2604. Humana Press, New York, NY. (Joint Editor)