影响因子：5.515

DOI码：10.18632/aging.102551

发表刊物：Aging-US (C刊)

摘要：Resveratrol (3,5,4′-trihydroxystilbene, RSV) is a natural potential anti-aging polyphenolic compound frequently used as a nutritional supplement against several diseases. However, the underlying mechanisms by which resveratrol regulates postovulatory aging of oocytes are still insufficiently known. In this study, we found that resveratrol could delay postovulatory aging and improve developmental competence of oocytes through activating selective mitophagy in the mouse. Resveratrol could maintain spindle morphology but it disturbed cortical granule (CG) distribution during oocyte aging. This might be due to upregulated mitophagy, since blocking mitophagy by cyclosporin A (CsA) treatment affected oocyte quality by damaging mitochondrial function and it decreased embryonic development. In addition, we also observed an involvement of FoxO3a in regulating mitophagy in aging oocytes following resveratrol treatment. Taken together, our results provide evidence that mitophagy induced by resveratrol is a potential mechanism to protect against postovulatory oocyte aging.

合写作者：He HN,Liu X,Yin SY,Wu DY,Zhang X,Schatten H

第一作者：Zhou JL#,Xue ZYY#

论文类型：期刊论文

通讯作者：Miao YL*

卷号：11

期号：23

页面范围：11504-11519

是否译文：否

发表时间：2019-12-13

收录刊物：SCI

发布期刊链接：https://www.aging-us.com/article/102551/text