个人/课题组简介

  胡晓攀，华中农业大学信息学院/生命科学技术学院教授、博士生导师，湖北洪山实验室研究员。入选国家级青年人才、湖北省创新人才支持计划。课题组依托华中农业大学信息学院和湖北洪山实验室，以微生物为研究对象，主要研究方向包括：（1）基于约束模型，系统解析微生物资源分配的优化机制；（2）运用系统发育学方法，揭示与目标性状相关的基因组特征；（3）整合系统生物学模型与符合进化规律的基因组特征，理性设计并优化原核生物基因组，实现资源分配的最优化。主要研究成果发表在Science、Nature Communications、PLOS Genetics、mSystems等国际主流学术期刊。

  课题组同时招收具备干实验或湿实验背景的学生，欢迎有生物学、生物信息学、计算机科学、统计学等相关学科背景的本科生、硕士/博士研究生加入。本课题组长期招聘博士后，欢迎通过邮件联系（xiao-pan.hu@mail.hzau.edu.cn）。

代表论文 Selected Publications

X.-P. Hu, B. Brahmantio, K. Bartoszek, M. J. Lercher, Most bacterial gene families are biased toward specific chromosomal positions. Science 388, 186-191 (2025).  https://www.science.org/stoken/author-tokens/ST-2562/full 

A. Kroll, Y. Rousset, X.-P. Hu, N. A. Liebrand, M. J. Lercher, Turnover number predictions for kinetically uncharacterized enzymes using machine and deep learning. Nat. Commun. 14, 4139 (2023).

X.-P. Hu, S. Schroeder, M. J. Lercher, Proteome efficiency of metabolic pathways in Escherichia coli increases along the nutrient flow. mSystems 8, e00760-23 (2023).

X.-P. Hu, M. J. Lercher, An optimal growth law for RNA composition and its partial implementation through ribosomal and tRNA gene locations in bacterial genomes. PLOS Genet. 17, e1009939 (2021).

X.-P. Hu, H. Dourado, P. Schubert, M. J. Lercher, The protein translation machinery is expressed for maximal efficiency in Escherichia coli. Nat. Commun. 11, 5260 (2020).

其他论文 Other publications

L. Tian, T. Liu, K.-J. Hua, X.-P. Hu, B.-G. Ma, The Spatial Organization of Bacterial Transcriptional Regulatory Networks. Microorganisms 10, 2366 (2022).

Y. Yang, X.-P. Hu, B.-G. Ma, Construction and simulation of the Bradyrhizobium diazoefficiens USDA110 metabolic network: a comparison between free-living and symbiotic states. Mol. BioSyst, 13, 607-620 (2017).

H.-R. Xu, J.-F. Cheng, X.-P. Hu, Y.-Y. Chu, B.-G. Ma, Are protein hubs faster folders? Exploration based on Escherichia coli proteome. Amino Acids 48, 2747-2753 (2016).

X.-P. Hu, Y. Yang, B.-G. Ma, Amino Acid Flux from Metabolic Network Benefits Protein Translation: the Role of Resource Availability. Sci. Rep. 5, 11113 (2015).

H. Xiong, Y. Yang, X.-P. Hu, Y.-M. He, B.-G. Ma, Sequence determinants of prokaryotic gene expression level under heat stress. Gene 551, 92-102 (2014).