摘要：Meiosis prepares the genome for sexual reproduction and is a driver of genetic diversity. Essential for both aspects are rapid chromosome movements enabling the pairing of homologous chromosomes, thereby promoting their recombination and ensuring their correct segregation afterward. However, it is unknown how meiocytes reorganize their nuclear architecture when chromosomes are tethered to the nuclear lamina in somatic cells. Here, we reveal the meiosis-specific Skp1–Cul1–F-box-protein (SCF) E3 ubiquitin ligase SCFRMF as a key regulator of this reorganization in Arabidopsis. We find that the nuclear lamina proteins of the CRWN family are degraded in an SCFRMF-dependent manner in this process. Thus, the SCFRMF functions to release the somatic constraints on chromosome mobility through disrupting the nuclear lamina, allowing homologous chromosomes to pair.

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发布期刊链接：https://www.science.org/doi/10.1126/sciadv.adr4567#core-collateral-metrics