周强伟,副研究员,博士毕业于华中农业大学,新加坡国立大学博士联合培养。主要研究方向为表观遗传学,包括DNA甲基化、三维基因组学方向的算法开发、数据库构建及数据分析。主持国自然青年基金、中央高校基本科研业务费专项基金,研究成果以通讯或第一作者(含共同)发表在Nucleic Acids Research (2021, 2022, 2023,2024)、Genome Biology(2022, 2023)、BMC Bioinformatics (2019, 2020)、Plant Physiology等期刊。
以通讯或第一作者(含共同)发表论文 (*表示通讯作者,#表示共同第一作者)
Liuyang Cai#, Jun Qiao#, Ruixin Zhou#, Xinyi Wang#, Yelan Li, Lei Jiang, Qiangwei Zhou*, Guoliang Li*, Tao Xu*, Yuliang Feng*, EXPRESSO: a multi-omics database to explore multi-layered 3D genomic organization, Nucleic Acids Research, 2024;, gkae99 (Breakthrough Article)
Zhou Qiangwei, Cheng S, Zheng S, Wang Z, Guan P, Zhu Z, Huang X, Zhou C, Li Guoliang*. ChromLoops: a comprehensive database for specific protein-mediated chromatin loops in diverse organisms. Nucleic Acids Research. 2023 Jan 16:gkac893.
Deng Li#, Zhou Qiangwei#, Zhou Jie, Cheng S, Shen J, Zhu Jian-Kang*, Li Guoliang*, and Zhao Lun*. 3D organization of regulatory elements for transcriptional regulation in Arabidopsis. Genome Biology. 2023 Aug; 24(1), 181.
Zhu Zhixian#, Zhou Qiangwei#, Sun Yuanhui#, Lai F, Wang Z, Hao Z, Li Guoliang*. MethMarkerDB: a comprehensive cancer DNA methylation biomarker database. Nucleic Acids Research. 2023, gkad923.
Zhou Qiangwei#, Guan Pengeng#, Zhu Zhixian#, Cheng S, Zhou C, Wang H, Xu Q, Sung WK, Li Guoliang*. ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms. Nucleic Acids Research. 2022 Jan 7;50(D1):D60-D71.
Zhao Lun#, Zhou Qiangwei#, He Li#, Deng L, Lozano-Duran R, Li Guoliang*, Zhu Jiankang*. DNA methylation underpins the epigenomic landscape regulating genome transcription in Arabidopsis. Genome Biology. 2022 Sep 20;23(1):197.
Zhou Qiangwei, Wang Z, Li J, Sung WK, Li Guoliang*. MethHaplo: combining allele-specific DNA methylation and SNPs for haplotype region identification. BMC Bioinformatics. 2020;21(1):451.
Zhou Qiangwei, Lim JQ, Sung Wing-Kin*, Li Guoliang*. An integrated package for bisulfite DNA methylation data analysis with Indel-sensitive mapping. BMC Bioinformatics. 2019;20(1):47.
Tan Feng#, Zhou Chao#, Zhou Qiangwei#, Zhou S, Yang W, Zhao Y, Li Guoliang, Zhou Daoxiu*. Analysis of Chromatin Regulators Reveals Specific Features of Rice DNA Methylation Pathways. Plant Physiology. 2016;171(3):2041-2054.
软件及数据库:
BatMeth2,DNA甲基化比对分析流程工具,https://github.com/GuoliangLi-HZAU/BatMeth2
MethHaplo,等位特异DNA甲基化(ASM)检测工具, https://github.com/ZhouQiangwei/MethHaplo
BSVC,DNA甲基化数据SNP检测工具,https://github.com/ZhouQiangwei/bsvc
DMtools,DNA甲基化结果压缩及分析工具,https://github.com/ZhouQiangwei/dmtools
ASMdb,等位特异DNA甲基化数据库, https://www.dna-asmdb.com/
MethMarkerDB,癌症DNA甲基化标志物数据库,https://methmarkerdb.hzau.edu.cn/
ChromLoops,特异蛋白介导的染色质远程交互数据库,https://3dgenomics.hzau.edu.cn/
EXPRESSO,三维多组学数据库,https://expresso.sustech.edu.cn
软件著作权
1. 周强伟、李国亮,计算机软件著作权,基于DNA甲基化数据的变异检测软件,2023SR0988707
2. 李国亮、周强伟,计算机软件著作权,DNA甲基化单倍型组装及等位特异性DNA甲基化检测软件,2023SR0991046
3. 李国亮、周强伟,计算机软件著作权,DNA甲基化结果压缩格式及操作工具,2023SR0734653
4. 李国亮、周强伟,计算机软件著作权,DNA甲基化分析流程软件,2019SR0582669