Other Contact Information:
张磊，博士，副教授，硕士生导师，入选湖北省“百人计划”（2024）。农业微生物资源发掘与利用全国重点实验室研究人员，国家动物结核病专业实验室（武汉）及农业农村部“牛病防治基础与技术创新团队”骨干成员。长期从事人与动物结核病的防治、结核杆菌代谢与致病机制等相关研究。学术成果发表在Nat Commun, Mol Cell, PLoS Pathog, Chem Rev, PNAS, JBC等国际权威期刊。课题组与国内外多个实验室建立了良好的合作关系，支持成员开展国际学习与交流。欢迎有志之士与我们一道投身结核病基础研究与防控工作，为WHO“2035终结结核病”计划贡献一份力量。
研究方向
（1）结核分枝杆菌代谢与致病机制；
（2）新药靶发掘与药物设计；
（3）开发抗结核新疫苗。
个人学术主页
https://www.researchgate.net/profile/Lei-Zhang-235
代表性论文（2020年之后）
Zhang L, Kent JE, Whitaker M, Young DC, Herrmann D, Aleshin AE, Ko YH, Cingolani G, Saad JS, Moody DB, Ehrt S, Marassi FM, Niederweis M (2022) A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis. Nat Commun 13:2255. PMID: 35474308
Zhang L, Hendrickson RC, Meikle V, Lefkowitz EJ, Ioerger TR, Niederweis M (2020) Comprehensive analysis of iron utilization by Mycobacterium tuberculosis. PLoS Pathog 16:e1008337. PMID: 32069330
Tan YZ, Zhang L, Rodrigues J, Zheng RB, Giacometti SI, Rosário AL, Kloss B, Dandey VP, Wei H, Brunton R, Raczkowski AM, Athayde D, Catalão MJ, Pimentel M, Clarke OB, Lowary TL, Archer M, Niederweis M, Potter CS, Carragher B, Mancia F (2020) Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria. Mol Cell 78:1-17. PMID: 32386575
Pajuelo D, Tak U, Zhang L, Danilchanka O, Tischler AD, Niederweis M (2021) Toxin secretion and trafficking by Mycobacterium tuberculosis. Nat Commun 12:6592. PMID: 34782620
Jackson M, Stevens CM, Zhang L, Zgurskaya HI, Niederweis M (2021) Transporters involved in the biogenesis and functionalization of the mycobacterial cell envelope. Chem Rev 121:5124-5157. PMID: 33170669
Tan YZ, Rodrigues J, Keener JE, Zheng RB, Brunton R, Kloss B, Giacometti SI, Rosário AL, Zhang L, Niederweis M, Clarke OB, Lowary TL, Marty MT, Archer M, Potter CS, Carragher B, Mancia F (2020) Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis. Nat Commun 11:3396. PMID: 32636380
Wang C, Jiang Y, Yang Z, Xu H, Khalid AK, Iftakhar T, Peng Y, Lu L, Zhang L, Bermudez L, Guo A, Chen Y (2024) Host factor RBMX2 promotes epithelial cell apoptosis by downregulating APAF-1's Retention Intron after Mycobacterium bovis infection. Front Immunol 15:1431207. PMID: 39308873
Geng Y, Jiang C, Yang H, Xia Q, Xu X, Yang K, Yuan X, Chen J, Chen Y, Chen X, Zhang L, Hu C, Guo A (2024) Construction of an IFNAR1 knockout MDBK cell line using CRISPR/Cas9 and its effect on bovine virus replication. Front Immunol 15:1404649. PMID: 39100665
