谢为博,华中农业大学信息学院教授,作物遗传改良全国重点实验室固定研究人员(2010-),国家自然科学基金优秀青年科学基金获得者(2019),湖北省创新群体项目主持人(2023),获校研究生指导教师“教书育人奖”(2020)。
研究领域为系统遗传学、计算基因组学和人工智能生物学。课题组关注三个递进的问题,即如何从种质资源中高效挖掘优异变异并解析其功能,如何理性设计与创造优异变异,如何组合优异变异以获得理想性状。围绕这些问题建立了从群体变异发现、因果基因鉴定、调控机制解析到田间验证的完整研究链条,发布了水稻基因组变异功能效应图谱 RiceVarMap、植物领域首个基于深度学习预测非编码变异调控效应的在线服务 PlantDeepSEA、水稻多组织调控组图谱 RiceRegMap 等公开资源,并作为主要设计人员合作开发了全球第一款水稻育种芯片。
主持国家自然科学基金5项,国家科技创新2030课题、国家重点研发计划课题和国家863计划专项子课题等10余项。发表科学研究论文100余篇,被引用1万余次,H-index为58。相关研究被Nature Plants、Genome Biology等杂志列为研究亮点,入选ESI Top 1%高被引论文和Top 1‰热点论文、入选全球前2%科学家榜单(2023)。
课题组愿景是“智驭生命密码,设计未来作物”。课题组具备独立产生多组学数据与开展实验验证的条件,既有数据分析为主的课题,也有与湿实验结合的课题,欢迎生物、数学、统计和计算机相关专业的青年朋友加入(作为硕博生、博士后和科研助理)。
课题组主页:https://xielab.hzau.edu.cn/
完整文章列表及引用情况请访问:
ORCID http://orcid.org/0000-0002-2768-3572
Google scholar http://scholar.google.com/citations?user=I5zjYOUAAAAJ
代表性论文:
Liu Y, Xia C, Li J, Li J, Yang H, Zong Z, Ming L, Yang J, Lian H, Luo M, Zhu T, He X, Xing Y, Yu S, Ouyang Y, Xie W*. GAMETE maps the genetic architecture of chromatin accessibility in rice pollen at single-nucleus resolution. Genome Biol, 2026, doi:10.1186/s13059-026-04226-4(建立单细胞遗传定位框架GAMETE,揭示水稻花粉细胞类型特异遗传调控与转座子沉默松弛期)
Li J, Xu X, Xia C, Liu Y, Ming L, Li W, Yang Y, Xie W*. Deep learning uncovers conserved regulatory logic and element dosage underlying stable gene expression in grasses. Mol Plant, 2026, 19: 1473(提出“调控等价”模型解释禾本科植物基因表达保守悖论)
Li W, Zhu X, Yang J, Zhou X, Ming L, Yang L, Li J, Tan Z, Xia C, Wang D, Xu X, Zong Z, Zhao H, Yang M, Xiong L, Lian X*, Xie W*. Chromatin accessibility dynamics and transcriptional regulatory networks underlying the primary nitrogen response in rice roots. Plant Commun, 2025, 6: 101392(以时间序列染色质可及性与转录组解析水稻氮素初级响应调控网络)
Xu X#, Jia Q#, Li S#, Wei J, Ming L, Yu Q, Jiang J, Zhang P, Yao H, Wang S, Xia C, Wang K*, Jia Z*, Xie W*. Redefining the accumulated temperature index for accurate prediction of rice flowering time in diverse environments. Plant Biotechnol J, 2024, doi:10.1111/pbi.14498 (重定义积温指数实现水稻抽穗期跨环境精准预测)
Zhu T#, Xia C#, Yu R, Zhou X, Xu X, Wang L, Zong Z, Yang J, Liu Y, Ming L, You Y, Chen D*, Xie W*. Comprehensive mapping and modelling of the rice regulome landscape unveils the regulatory architecture underlying complex traits. Nat Commun, 2024, 15: 6562 (绘制迄今最全面的水稻染色质可及性图谱,构建深度学习模型)
Liu Y, Zhan J, Li J, Lian M, Li J, Xia C, Zhou F, Xie W*. Characterization of the DNA accessibility of chloroplast genomes in grasses. Commun Biol, 2024, 7: 760 (意外发现,绘制叶绿体DNA可及性图谱)
Ming L#, Fu D#, Wu Z, Zhao H, Xu X, Xu T, Xiong X, Li M, Zheng Y, Li G, Yang L, Xia C, Zhou R, Liao K, Yu Q, Chai W, Li S, Liu Y, Wu X, Mao J, Wei J, Li X, Wang L, Wu C*, Xie W*. Transcriptome-wide association analyses reveal the impact of regulatory variants on rice panicle architecture and causal gene regulatory networks. Nat Commun, 2023, 14: 7501 (开发TWAS新方法鉴定水稻穗型变异的因果基因及其调控网络)
Tan Z, Peng Y, Xiong Y, Xiong F, Zhang Y, Guo N, Tu Z, Zong Z, Wu X, Ye J, Xia C, Zhu T, Liu Y, Lou H, Liu D, Lu S, Yao X, Liu K, Snowdon RJ, Golicz AA, Xie W*, Guo L*, Zhao H*. Comprehensive transcriptional variability analysis reveals gene networks regulating seed oil content of Brassica napus. Genome Biol, 2022, 23: 233 (揭示油菜含油量的基因调控网络)
Wang P#, Qi F#, Yao H#, Xu X, Li W, Meng J, Zhang Q, Xie W*, Xing Y*. Fixation of hybrid sterility genes and favorable alleles of key yield-related genes with dominance contribute to the high yield of the Yongyou series of intersubspecific hybrid rice. J Genet Genomics, 2022, 49: 448-457 (解析甬优籼粳交杂种高产的遗传基础)
Yu H, Li M, Sandhu J, Sun G, Schnable JC, Walia H, Xie W*, Yu B*, Mower JP*, Zhang C*. Pervasive misannotation of microexons that are evolutionarily conserved and crucial for gene function in plants. Nat Commun, 2022, 13: 820 (植物微外显子分析)
Zhao H, Li J, Yang L, Qin G, Xia C, Xu X, Su Y, Liu Y, Ming L, Chen L, Xiong L and Xie W*. An inferred functional impact map of genetic variants in rice. Mol Plant, 2021, 14: 1584 (构建水稻基因组序列变异的功能效应图谱,通过深度学习模型首次系统注释水稻非编码变异的调控效应,ESI高被引)
Zhao H#, Tu Z#, Liu Y, Zong Z, Li J, Liu H, Xiong F, Zhan J, Hu X, Xie W*. PlantDeepSEA, a deep learning-based web service to predict the regulatory effects of genomic variants in plants. Nucleic Acids Res, 2021, 49: W523 (植物中首个基于深度学习模型预测基因组序列变异调控效应的网络服务)
Tang S#, Zhao H#, Lu S, Yu L, Zhang G, Zhang Y, Yang Q, Zhou Y, Wang X, Ma W, Xie W*, Guo L*. Genome- and transcriptome-wide association studies provide insights into the genetic basis of natural variation of seed oil content in Brassica napus. Mol Plant, 2021, 14: 470 (开发算法POCKET鉴定GWAS候选基因,揭示油菜籽粒含油量自然变异的遗传基础,ESI高被引)
Zhu T#, Liao K#, Zhou R#, Xia C, Xie W*. ATAC-seq with unique molecular identifiers improves quantification and footprinting. Commun Biol, 2020, 3: 675 (开发UMI-ATAC-seq技术,更准确地定量染色质可及性和鉴定转录因子足迹)
Yao W, Li G, Zhao H, Wang G, Lian X, Xie W*. Exploring the rice dispensable genome using a metagenome-like assembly strategy. Genome Biol, 2015, 16: 187 (基于1483份水稻材料群体水平首次探索水稻泛基因组,当期杂志配发亮点评论"Harvesting rice's dispensable genome")
Xie W#, Wang G#, Yuan M, Yao W, Lyu K, Zhao H, Yang M, Li P, Zhang X, Yuan J, Wang Q, Liu F, Dong H, Zhang L, Li X, Meng X, Zhang W, Xiong L, He Y, Wang S, Yu S, Xu C, Luo J, Li X, Xiao J, Lian X*, Zhang Q*. Breeding signatures of rice improvement revealed by a genomic variation map from a large germplasm collection. Proc Natl Acad Sci USA, 2015, 112: E5411-E5419 (揭示水稻改良的"育种印迹",Nature Plants配发亮点评论"Rice breeding: Signature analysis")
Zhao H, Yao W, Ouyang Y, Yang W, Wang G, Lian X, Xing Y, Chen L, Xie W*. RiceVarMap: a comprehensive database of rice genomic variations. Nucleic Acids Res, 2015, 43: D1018-1022
Wang Q#, Xie W#, Xing H, Yan J, Meng X, Li X, Fu X, Xu J, Lian X, Yu S, Xing Y, Wang G*. Genetic Architecture of Natural Variation in Rice Chlorophyll Content Revealed by a Genome-Wide Association Study. Mol Plant, 2015, 8: 946-957
Chen W#, Gao Y#, Xie W#, Gong L#, Lu K#, Wang W, Li Y, Liu X, Zhang H, Dong H, Zhang W, Zhang L, Yu S, Wang G, Lian X*, Luo J*. Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism. Nat Genet, 2014, 46: 714-721 (ESI高被引)
Chen H#, Xie W#, He H#, Yu H#, Chen W, Li J, Yu R, Yao Y, Zhang W, He Y, Tang X*, Zhou F*, Deng X W*, Zhang Q*. A High-Density SNP Genotyping Array for Rice Biology and Molecular Breeding. Mol Plant, 2014, 7: 541-553 (ESI高被引)
