其他联系方式
赖雪雷，华中农业大学生命科学技术学院教授、博士生导师，作物遗传改良全国重点实验室及湖北洪山实验室研究员。入选国家高层次青年人才项目，主持国家重点研发计划青年科学家项目、国家自然科学基金面上项目和湖北省自然科学基金杰出青年等项目。2013至2016年在欧洲同步辐射光源中心（The European Synchrotron）开展博士课题研究，获得荷兰格罗宁根大学（University of Groningen）生物化学与分子生物学博士学位。2016至2021年，先后在英国剑桥大学Sainsbury实验室和法国国家科学院（CNRS）从事博士后研究。
课题组现隶属于作物遗传改良全国重点实验室--水稻团队--非生逆境亚团队（熊立仲主持）。目前主要以主粮作物水稻为研究对象，解析水稻感知环境与胁迫信号的遗传与分子基础，尤其是温度信号，包括高温（>38°C）、低温（<10°C）和环境温度（20-32°C），为水稻的环境适应性遗传改良提供基因资源和理论基础。以通讯作者（含共同）在Cell、EMBO Journal、Nature Communications和Molecular Plant等国际知名期刊发表论文，为Molecular Plant和Current Opinion in Plant Biology等期刊撰写综述文章。以合作者身份在Nature、Cell、Nature Plants和Plant Cell等期刊发表论文。
关键词：水稻；逆境感知；温度逆境；自然变异；遗传改良；绿色营养超级稻；分子机制；生物大分子凝聚体
Xuelei Lai is a professor at the College of Life Science and Technology at Huazhong Agricultural University, as well as a researcher at the National Key Laboratory of Crop Genetic Improvement and Hubei Hongshan Laboratory in Wuhan, China. He earned his Ph.D. from the University of Groningen in the Netherlands in 2016. From 2016 to 2021, he conducted postdoctoral research at the University of Cambridge and the French National Centre for Scientific Research, focusing on plant temperature sensing and flower development.
Currently, Dr. Lai's laboratory investigates how rice (Oryza sativa) senses abiotic stress signals, with an emphasis on temperature stresses, including low, high, and high ambient temperatures. His goal is to develop climate-resilient rice varieties to address the challenges posed by a growing global population in the context of climate change.
Keywords: rice; stress sensing; temperature stress; natural variation; genetic improvement; molecular mechanism; biomolecular condensates; genome design and engineering; green nutritious super rice
科研项目
主持国家自然科学基金委面上项目： 水稻OsSRO1c蛋白相变介导高低温感知与应答的分子机制研究（2025）
主持国家重点研发计划青年科学家项目：水稻生殖发育期耐高温机制和遗传改良（2023）
主持科技部“中法科研伙伴交流计划”项目：一个水稻转录调控复合体的相分离介导的低温感应机制研究（2023）
主持国家科技重大专项子课题：耐非生物逆境新基因挖掘与育种价值评价（2023）
主持湖北省自然科学基金杰出青年项目：水稻高温感应机制和遗传改良（2023）
主持国家自然科学基金委面上项目：生物钟蛋白ELF3介导的温度感应机制研究（2022）
主持华中农业大学海外高层次人才项目：水稻温度感知和遗传改良（2021）
人才项目
2024年 国家万人计划（青年拔尖人才）
2023年 国家重点研发计划（青年项目）首席科学家
2023年 湖北省自然科学基金杰出青年
2022年 湖北省“百人计划”（创新人才-省重点联系专家）
2021年 武汉英才计划（优秀青年人才）
2017年 国家优秀自费留学生奖（荷兰领区）
科研与学术工作经历
2021-现在 作物遗传改良全国重点实验室，固定研究人员
2021-现在 湖北洪山实验室，固定研究人员
2021-现在 华中农业大学，生命科学技术学院，教授
2017-2021 法国国家科学院，博士后
2016-2017 英国剑桥大学，博士后
Academic positions
2021-Present: Principal Investigator, National Key Laboratory of Crop Genetic Improvement, Wuhan, China
2021-Present: Principal Investigator, Hubei Hongshan Laboratory, Wuhan, China
2021-Present: Full Professor, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China
2017-2021: Postdoc, The French National Centre for Scientific Research (Francois Parcy and Chloe Zubieta laboratory), Grenoble, France
2016-2017: Postdoc, The Sainsbury Laboratory, University of Cambridge (Philip A. Wigge), Cambridge, UK
教育经历
2013-2016 荷兰格罗宁根大学，生物化学与分子生物学，博士学位
2009-2012 吉林大学，食品科学与工程，硕士学位
2005-2009 长春工业大学，食品科学与工程，学士学位
Education
2013-2016: University of Groningen (Bauke W. Dijkstra laboratory), Groningen, The Netherlands, PhD in biochemistry and molecular biology
2009-2012: Jilin University, Changchun, Jilin, China, master’s in food science and technology
2005-2009: Changchun University of Technology, Changchun, Jilin, China, bachelor’s in food science and technology
个人学术主页：PubMed, Google scholar, ORCID, ResearchGate
代表性成果（#一作; *通讯）
Tu H#, Liu Q#, Ye T#, Ye Y, Feng X, Shen L, Li S, Bai S, Liu X, Liu X, Wang H, Li X, Lin J, Wang H, Chen Y, Feng Z, Ji B, Ding J, Li W, Zhang J, Dai M, Dong F, Hu H, Tang N, Lai X*, Xiong H*, Xiong L*. (2026). An Oryza orphan gene confers trans-species drought tolerance. Cell, doi: 10.1016/j.cell.2026.07.005
Zhang Y, Li B, Chen Y, Li J, Wang Y, Ye T, Ye Y, Liu Z, Feng Z, Hutin S, Zhou S, Guo J, Zhang R, Liu Z, Dong F, Xiong H, Zubieta C, Xiong L*, Lai X*. (2026). The TPR2 corepressor forms condensates with repressors to fine-tune growth and development in rice. EMBO Journal, doi: 10.1038/s44318-026-00852-7.
Lv Q#, Li J#, Liu C, Samraoui K, Hutin S, Li X, Dong F, Xiong H, Ouyang Y, Hu H, Li B, Hepworth J, Jung JH, Chen X, Zubieta C, Xiong L, Zhao Y*, Clemente‐Moreno M*, Fang X*, Flashman E*, Kudla J*, Lai X*. (2026). Abiotic Stress Sensing in Plants: Biochemical and Biophysical Basis. Molecular Plant, S1674-2052(26)00150-4.
Wang H#, Ye T#, Guo Z, Yao Y, Tu H, Wang P, Zhang Y, Wang Y, Li X, Li B, Xiong H, Lai X*, Xiong L*. (2024). A double-stranded RNA binding protein enhances drought resistance via protein phase separation in rice. Nature Communications, 15 (2514).
Hu D, Yao Y, Lv Y, You J, Zhang Y, Lv Q, Li J, Hutin S, Xiong H, Zubieta C, Lai X*, Xiong L*. (2024). The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice. Molecular Plant, 17(10):1520-1538.
Lai X#, Vega-Léon R#, Hugouvieux V#*, Blanc-Mathieu R, van der Wal F, Lucas J, Silva CS, Jourdain A, Muino JM, Nanao MH, Immink R, Kaufmann K, Parcy F, Smaczniak C*, Zubieta C*. (2021). The Intervening Domain Is Required For DNA-binding and Functional Identity of Plant MADS Transcription Factors. Nature Communications, 12 (4760).
Lai X#, Blanc-Mathieu R#, GrandVuillemin L, Huang Y, Stigliani A, Lucas J, Thévenon E, Loue-Manifel J, Turchi L, Daher H, Brun-Hernandez E, Vachon G, Latrasse D, Benhamed M, Dumas R, Zubieta C, Parcy F*. (2021). The LEAFY floral regulator displays pioneer transcription factor properties. Molecular Plant, 14(5):829-837.
Lai X#, Stigliani A#, Lucas J, Hugouvieux V, Parcy F*, Zubieta C*. (2020). Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing. Nucleic Acids Research, 48 (17), 9637–9648.
Silva CS#, Nayak A#, Lai X#, Hutin S*, Hugouvieux V, Jung JH, López-Vidriero I, Franco-Zorrilla JM, Panigrahi KCS, Nanao MH, Wigge PA, Zubieta C*. (2020). Molecular mechanisms of Evening Complex activity in Arabidopsis. Proceedings of the National Academy of Sciences, 117 (12), 6901–6909.
Lai X#, Chahtane H#, Martin-Arevalillo R, Zubieta C, Parcy F*. (2020). Contrasted evolutionary trajectories of plant transcription factors. Current Opinion in Plant Biology, 54, 101–107.
Lai X#*, Stigliani A#, Vachon G, Carles C, Smaczniak C, Zubieta C, Kaufmann K, Parcy F*. (2019). Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants. Molecular Plant, 12 (6), 743–763.
Lai X, Wichers HJ, Soler-Lopez M*, Dijkstra BW*. (2018). Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins. Chemistry, 24(1):47-55
Lai X, Wichers HJ, Soler-Lopez M*, Dijkstra BW*. (2017). Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angewandte Chemie International Edition, 56 (33), 9812–9815.
其它研究成果
Dahro B, Khan M, Chu L, Zhu J, Shang X, Zeng X, Wu X, Hu W, Lai X, Li C, Liu JH*. (2026). TAF1 and GCN5-mediated histone acetylation of regulatory cascade AHL14/17-A/NINV7 promotes sucrose catabolism and sugar accumulation for cold tolerance in Citrus. New Phytologist, 251(3):1221-1241
Yue Y, Lu T, Guo X, Liu B, Lv S, Abdalla HAM, Lai X, Zhang R, Guo J, Zhao Y, Zhou DX, Zhou S*. (2026). ADA2 Forms Nuclear Condensates with GCN5 and ATP-Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems. Advanced Science, 13(5):e13169.
Hutin S, Li J, Tully MD, Lai X, Zubieta C*. (2026). Transcriptional outputs and condensates - formation and function. New Phytologist, 249(3):1145-1154.
Du Z, Guan Z, Liu H, Zhang J, He H, Zheng Z, Zhang W, Jiang L, Zuo J, Liu Y, Wan B, Tu H, Dong F, Lai X, Xiong L, Yin P, Xue S, Chen Y, Liu Z* (2026). Cryo-EM structure and dynamic basis of phosphate uptake by PHT1 in rice. Developmental Cell, 61(1):164-177.e6
Xiang D#, Tu H#, Yuan Y, Yao Y, Liao W, Wang H, Yan Y, Wang Y, Chen Y, Liu D, Lv Q, He H, Hu H, Lai X, Yuan M, Xiong H, Dong F*, Xiong L*. (2025). A Blast-Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia-Lyase in Rice, Advanced Science, 12(39):e02662.
Ye T#, Wang H#, Zhang L, Li X, Tu H, Guo Z, Gao T, Zhang Y, Ye Y, Li B, Yang W, Li Y, Lai X, Dong F, Xiong H*, Xiong L*. (2025). A novel OsCRK14-OsRLCK57-MAPK signaling module activates OsbZIP66 to confer drought resistance in rice. Molecular Plant, 18(8):1390-1408
Zhang J, You L, Liu H, Luo S, Li R, Xue S, Lai X, Hu H*. (2025). Fe-deficiency-induced chlorosis 1 is essential for chloroplast iron transport and homeostasis under continuous light conditions in Arabidopsis, Cell Reports, 44(7):115942
Lou G, Chen P, Li P, Gao H, Xiong J, Wan S, Zheng Y, Wang Y, Alam M, Chen Y, Wang L, Bai J, Tan X, Rao W, Wu B, Zhou H, Li Y, Gao G, Zhang Q, Xiao J, Li X, Lai X, Zhang Q, He Y*. (2025). Antagonistic Ghd7-OsNAC42 Complexes Modulate Carbon and Nitrogen Metabolism to Achieves Superior Quality and High Yield in Rice, Advanced Science, 12(31):e04163
Li W, Yang K, Hu C, Abbas W, Zhang J, Xu P, Cheng B, Zhang J, Yin W, Shalmani A, Qu L, Lv Q, Li B, He Y, Lai X, Xiong L, Zhang Q, Li Y*. (2025). A natural gene on-off system confers field thermotolerance for grain quality and yield in rice. Cell, 188(14):3661-3678.e21.
Zubieta C, Hutin S, Jung JH, Lai X*. (2024). Phosphorylation of PHYB by GSK3S, a key mechanism that brings temperature sensors together. New Phytologist, 245(4):1335-1337.
Thoris K, Correa Marrero M, Fiers M, Lai X, Zahn IE, Jiang X, Mekken M, Busscher S, Jansma S, Nanao M, de Ridder D, van Dijk ADJ, Angenent GC, Immink RGH, Zubieta C, Bemer M*. (2024). Uncoupling FRUITFULL’s functions through modification of a protein motif identified by co-ortholog analysis. Nucleic Acids Research, 52(21):13290-13304.
Hugouvieux V, Blanc-Mathieu R, Janeau A, Paul M, Lucas J, Xu X, Ye H, Lai X, Le Hir S, Guillotin A, Galien A, Yan W, Nanao M, Kaufmann K, Parcy F, Zubieta C*. (2024). SEPALLATA-driven MADS transcription factor tetramerization is required for inner whorl floral organ development. Plant Cell, 36(9):3435-3450.
Li W, Yan J, Zhang Y, Zhang F, Guan Z, Yao Y, Chang Y, Tu H, Li X, Wang H, Xiong H, Lai X, Yin P, Xiong L*. (2023). Serine protease NAL1 exerts pleiotropic functions through degradation of TOPLESS-related corepressor in rice. Nature Plants, 9(7), 1130-1142.
Jung JH#, Barbosa AD#, Hutin S#, Kumita JR, Gao M, Derwort D, Silva CS, Lai X, Pierre E, Geng F, Kim SB, Baek S, Zubieta C, Jaeger KE, Wigge PA*. (2020). A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature, 585, 256–260.
Ezer D, Jung JH, Lan H, Biswas S, Gregoire L, Box MS, Charoensawan V, Cortijo S, Lai X, Stöckle D, Zubieta C, Jaeger KE, Wigge PA*. (2017). The evening complex coordinates environmental and endogenous signals in Arabidopsis. Nature Plants, 3, 17087.
学术报告/talks
Upcoming
Selected talk, International Symposium on Rice Functional Genomics (ISRGF) 2026, 8th–10th Sept. 2026, London, United Kingdom: A temperature-dependent protein phase transition underlies bidirectional cold and heat stress tolerance in rice.
Invited talk, Thermomorphogenesis 2026, 26th–28th Aug. 2026, Dundee, Scotland, United Kingdom: Thermosensory flowering in rice.
Selected talk, Scandinavian Plant Physiology Society Congress (SPSS) 2026, 18th–20th Aug. 2026, Helsinki, Finland: Functions of biomolecular condensates in transcriptional regulation and stress responses in plants.
2026
Invited talk, Consejo Superior de Investigaciones Científicas (CSIC), 6th July 2026, Madrid, Spain: The functions of (un)structured proteins in plant stress responses.
Invited talk, Workshop on the Molecular Mechanisms Controlling Flower Development, 15th–19th June 2026, Presqu’île de Giens, France: Thermosensory flowering in rice.
Selected talk, Salt and Water Stress in Plants (Gordon Research Conference), 25th–29th May 2026, Les Diablerets, Switzerland: Protein phase separation in stress sensing and responses in rice.
Invited webinar, Bio-protocol, 27th Apr. 2026, online: Biocondensates at the interface of gene regulation and environmental responses in plants.
Invited talk, Department of Biology, Oxford University, 18th Jan. 2026, Oxford, United Kingdom: Functions of biocondensates in transcriptional regulation and stress responses in plants.
2025
受邀报告，2025年重庆大学含弘作物学论坛暨作物学博士生国际论坛，2025年11月30日，重庆：Protein phase separation in abiotic stress sensing in rice.
受邀报告，The 5th Belt and Road Sino-Pakistan Agriculture Forum，2025年11月19日，湖北武汉，华中农业大学：Protein phase separation in abiotic stress sensing in rice.
Selected talk, Plant Proteins: Functions, Regulation, Production and Utility, 21st–23rd Oct. 2025, University of Leeds, Leeds, United Kingdom: Protein phase separation in abiotic stress sensing and responses in rice.
受邀报告，第9届中国植物蛋白质研究大会，2025年9月26–30日，山东烟台：水稻逆境感知与遗传改良。
受邀报告，2025 International Symposium on Rice Functional Genomics，2025年8月23–27日，四川成都：Protein phase separation in abiotic stress sensing and responses in rice.
受邀报告，黑龙江省农业科学院水稻重大任务集成创新体系暨寒地粳稻新优品种现场观摩及学术交流会，2025年8月12日，黑龙江佳木斯：水稻逆境感知与遗传改良。
Selected talk, Plant Biology 2025, American Society of Plant Biologists, 26th–30th July 2025, Milwaukee, Wisconsin, United States: Protein phase separation in stress signal sensing and responses in rice.
Selected talk, Iberian Congress of Plant Biology 2025 (IPB-25), 3rd July 2025, Murcia, Spain: Protein phase separation in stress signal sensing and responses in rice.
受邀报告，第六届全国植物逆境生物学学术研讨会，2025年5月10–13日，山东青岛：水稻温度逆境与遗传改良。
2024
Selected talk, Perspectives on Protein Networks in Plants Symposium, 19th–20th Sept. 2024, Strasbourg, France: Protein phase separation in stress signal sensing and responses in rice.
Selected talk, Society for Experimental Biology Conference, 2nd–5th July 2024, Prague, Czech Republic: The OsSRO1c–OsDREB2B complex confers cold tolerance via protein phase separation in rice.
欢迎加入我们
实验室依托作物遗传改良全国重点实验室和湖北洪山实验室，招收博士后1-2名（常年有效）、博士研究生1-2名/年和硕士研究生2-4名/年。欢迎对“气候变化”、“温度感应”、“作物遗传改良”和“植物环境适应性”等关键词感兴趣的有志之士加入。
Come and join us
We are part of the National Key Laboratory of Crop Genetic Improvement and the newly established Hubei Hongshan Laboratory, which are both among the most advanced and promising plant and crop research centers in China. Our lab is recruiting postdoc researchers (1-2), PhD students (1-2 per year) and master students (2-4 per year). We welcome motivated researchers and students who are interested in key words, e.g., climate change, temperature sensing, crop genetic improvement, plant adaptation to environmental stresses, to join us. We provide competitive salary, housing and state-of-the-art research facilities.
Address
湖北省武汉市洪山区狮子山街1号华中农业大学第二综合楼 B612
B612, National Key Laboratory of Crop Genetic Improvement,
Hubei Hongshan Laboratory, Huazhong Agricultural University,
No.1, Shizishan Street, Hongshan District, Wuhan, Hubei Province, P.R.China
Email:
xuelei_lai@hotmail.com — preferred contact address
xuelei_lai@mail.hzau.edu.cn — institutional email address
