个人简介

华中农业大学生命科学技术学院教授，湖北洪山实验室研究员，泰山学者。获2023年青年酶工程学家奖。任中国医药生物技术协会酶工程与发酵工程专业委员会委员，山东省专业标准化技术委员会委员，华农农化联合会常务理事，《Engineering Microbiology》期刊青年编委。研究方向为微生物合成生物学、酶学与酶工程、工业微生物菌种改造。致力于微生物活性天然产物生物合成与结构多样化研究工作，以具有杀虫、杀菌等重要生物活性分子为研究对象，系统揭示其生物合成机理，人工设计酶元件和生物合成途径，实现新结构产物的理性创造。发表论文30余篇，代表论文发表于Nature Catalysis、Chemical Reviews、JACS、Angew、PNAS、ACS Catalysis等。近年来主持国家、省部级、地方和横向项目20余项，主要包括国家重点研发计划子课题、国家自然科学基金项目、省自然科学基金项目、国家博士后创新人才支持计划等。与企业合作开展工业微生物菌种构建和改造工作，相关技术投入产业化应用。

研究方向

微生物合成生物学、酶学与酶工程、工业微生物菌种改良

发表论文

• Ye Y.^#, Du L.^#, Zhang X., Newmister S.A., McCauley M., Alegre-Requena J.V., Zhang W., Mu S., Minami A., Fraley A.E., Adrover-Castellano M.L., Carney N.A., Shende V.V., Qi F., Oikawa H., Kato H., Tsukamoto S., Paton R.S., Williams R.M.^*, Sherman D.H.*, and Li S.* Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nature Catalysis, 2020, 3: 497-506.

• Du L.^#, Dian L.^#, Newmister A.S., Xia Y., Luo G., Sherman D.H.*, Li S.* The mutually inspiring biological and chemical synthesis of fungal bicyclo[2.2.2]diazaoctane indole alkaloids. Chemical Reviews, 2025, 125: 1718-1804.

• Xia Y.^#, Zhu G.^#, Zhang X.^#, Li S., Du L.*, Zhu W.* Biosynthesis of 4-acyl-5-aminoimidazole alkaloids featuring a new Friedel–Crafts acyltransferase. Journal of The American Chemical Society, 2023, 145: 26308-26317.

• Zhang C.^#, Zhou J.^#, Wang W.^#, Liu M.^#, Li Y., Sheng X.*, Du L.*, and Li S.* Oxidative electrocyclization assembles 2,2-dimethyl-2H-pyran in fungal indole alkaloids. Angewandte Chemie International Edition, 2025, 64: e202506276.

• Du L.^#, Dong S.^#, Zhang X., Jiang C., Chen J., Yao L., Wang X., Wan X., Liu X., Wang X., Huang S., Cui Q., Feng Y.*, Liu S.-J.*, and Li S.* Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system. Proceedings of the National Academy of Sciences of the United States of America, 2017, 114: E5129-E5137.

• Zhang W.^#, Du L.^#, Li F., Zhang X., Qu Z., Han L., Li Z., Sun J., Qi F., Yao Q., Sun Y., Geng C., and Li S.* Mechanistic insights into interactions between bacterial class I P450 enzymes and redox partners. ACS Catalysis, 2018, 8: 9992-10003.

• Zhang C., Du L.*, Li S.* Engineering a virus-derived X family DNA polymerase FvPolX for de novo DNA synthesis. Advanced Science, 2026, 0: e75017.

• Qiu Z., Han Y., Li J., Ren Y., Liu X., Li S.*, Zhao G.*, Du L.* Metabolic division engineering of Escherichia coli consortia for de novo biosynthesis of flavonoids and flavonoid glycosides. Metabolic Engineering, 2025, 89: 60-75.

• Zhang C., He Z., Gao Z., Meng C., Peng W.*, Du L.*, Li S.* Semi-rational engineering of terminal deoxynucleotidyl transferase for high-efficiency enzymatic de novo DNA synthesis. Synthetic and Systems Biotechnology, 2026, 13: 519-530.

• Subthain H., Guo F., Zhang C., Fang P., Zhang L., Su Q., Tang D. Chi L., Liu C., Urlacher V. B., Li J.*, Du L.*, Li S.* Functional characterization of four glycosyltransferases for biosynthesis of steroidal saponins in medicinal plant Paris polyphylla. Synthetic and Systems Biotechnology, 2026, 14: 117-127.

• Yan B., Han Y., Mu S., Qiu Z.*, Du L.* Research progress and prospects of open-chain flavonoid biosynthesis. ACS Synthetic Biology, 2026, 15: 955-970.

• Tang D., Zheng X., Zhao Y., Zhang C., Chen C., Chen Y., Du L.*, Liu K.*, Li S.* Engineered microbial consortium for de novo production of sclareolide. Journal of Agricultural and Food Chemistry, 2024, 72: 19977-19984.

• Li M.^#, You C.^#, Guo F.^#, Han Q., Xie X., Ma L., Li S., Du L.*, Sheng X.* and Su H.* Reaction mechanism and regioselectivity of uridine diphosphate glucosyltransferase RrUGT3: a combined experimental and computational study. Catalysis Science & Technology, 2024,14: 4882-4895.

• Qiu Z.#, Liu X.#, Yu J., Zhao Y., Zhao G.-R., Li S., Liu K.*, Du L.*, Ma L.* Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases. Synthetic and Systems Biotechnology, 2024, 9: 187-195.

• Zhao D., Huo X., Li P., Yuan X., Li S., Du L.*, Huang L.*, Zhang P.* Asperinamide A, an anti-inflammatory prenylated indole alkaloid possessing an unprecedented bicyclo[2.2.2]diazaoctane fused with substituted piperidine scaffold from Aspergillus sp. TE-65L. Tetrahedron, 2023, 149: 133744.

• Guo F.^#, Zhang X.^#, You C., Zhang C., Li F., Li N., Xia Y., Liu M., Qiu Z., Zheng X., Ma L., Zhang G., Luo L., Cao F., Feng Y., Zhao G., Zhang W., Li S., Du L.* Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity. Microbial Cell Factories, 2022, 21: 208.

• Du L., Li S.* Compartmentalized biosynthesis of fungal natural products. Current Opinion in Biotechnology, 2021, 69: 128-135.

• Dong S.^#, Chen J.^#, Zhang X., Guo F., Ma L., You C., Wang X., Zhang W., Wan X., Liu S.-J., Yao L.-S., Li S., Du L.*, and Feng Y.* Structural basis for selective oxidation of phosphorylated ethylphenols by cytochrome P450 monooxygenase CreJ. Applied and Environmental Microbiology, 2021, 87: e00018-21.

• Du L., Ma L., Qi F., Zheng X., Jiang C., Li A., Wan X., Liu S.-J.*, and Li S.* Characterization of a unique pathway for 4-cresol catabolism initiated by phosphorylation in Corynebacterium glutamicum. Journal of Biological Chemistry, 2016, 291: 6583-6594.

• Du L., Liu R.-H., Ying L., and Zhao G.-R.* An efficient intergeneric conjugation of DNA from Escherichia coli to mycelia of the lincomycin-producer Streptomyces lincolnensis. International Journal of Molecular Sciences, 2012, 13: 4797-4806.

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主持项目

• 国家重点研发计划“合成生物学”重点专项子课题，青年项目，2021.10-2026.09

• 国家重点研发计划“合成生物学”重点专项子课题，2020.11-2025.10

• 国家重点研发计划“农业面源、重金属污染防控和绿色投入品研发”重点专项子课题，2025.12-2028.11

• 国家自然科学基金面上基金，2024.01-2027.12

• 国家自然科学基金面上基金，2022.01-2025.12

• 国家自然科学基金青年科学基金，2019.01-2021.12

• 山东省自然科学基金重大基础研究项目，2021.01-2023.12

• 山东省泰山学者青年专家项目，2024.01-2026.12

• 中央高校优秀青年团队项目，2023-2025

• 山东省高等学校青创科技计划创新团队，2021.06-2024.05

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