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陈小林

博士生导师
硕士生导师
教师姓名:陈小林
教师拼音名称:chenxiaolin
电子邮箱:
所在单位:植物科学技术学院
学历:博士研究生毕业
办公地点:分子楼111
学位:博士学位
职称:教授
在职信息:在职
毕业院校:中国农业大学
所属院系:植物科学技术学院
其他联系方式

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个人简介

陈小林:男,1981年8月出生,教授,博士生导师,湖北荆门人,农业微生物资源发掘与利用全国重点实验室固定研究人员,华中农业大学植物科学技术学院教师。在植物病理教研室从事教学和科研工作,主讲本科生《分子植物病理学》和研究生《植物病原真菌致病分子机制》。长期从事稻瘟病研究工作,中国植物保护学会青年委员会委员。以通讯作者或第一作者在Ann Rev Phytopathol,Plant Cell,New Phytol,Plant Biotechnol J,PLOS Pathog,PLOS Genet,ACS Appl Mater Interfaces,Environ Microbiol,Mol Plant Pathol,Front Microbiol,Front Plant Sci等期刊发表论文32篇,先后主持国家自然科学基金5项。

学习工作经历:

2000.9-2004.6:华中农业大学植物保护系,本科

2004.9-2011.6:中国农业大学植物病理学专业,硕博连读

2011.7-2014.10:中国农业大学作物遗传育种专业,博士后

2014.10-2015.3:北京市农林科学院,科研助理

2015.3-2021.11:华中农业大学,副教授

2019.10-2020.8:英国The Sainsbury Laboratory/John Inners Centre,访问学者

2021.12-至今:华中农业大学,教授

研究内容

以稻瘟菌-水稻作为模式系统,进行真菌致病分子机制,病原真菌-植物互作分子机制研究。以解析致病过程分子调控机制为目的,综合运用功能基因组学,分子遗传学,分子细胞生物学,修饰蛋白组学,表观遗传修饰组学等手段进行研究。为其它非模式病原真菌和非模式寄主植物提供借鉴,为开发新型杀菌剂提供候选靶标,为发现新的真菌病害防控途径,乃至培育抗病品种提供理论依据和应用基础。

当前主要研究方向:

1)植物病原真菌致病过程的翻译后修饰调控机制

2)植物病原真菌致病过程的表观遗传学调控机制

3)真菌-寄主互作过程的免疫逃避机制

4)真菌绿色杀菌剂开发

实验室积极欢迎本科生参与硕彦计划项目,欢迎推免生(硕士或博士)和博士后申请,有意者请将简历发送至chenxiaolin@mail.hzau.edu.cn


科研项目

1. 国家重点研发计划项目子课题,水稻抗/感稻瘟病相关重要微生物组和代谢化合物鉴定及作用机制,课题编号:2022YFA1304402-03,项目年限:2022/12-2026/11(子课题主持)

2. 国家自然科学基金面上项目,ERF2介导的棕榈酰化修饰调控稻瘟菌附着胞功能的分子机制研究. 课题编号:32272476, 项目年限:2023/1-2026/12(主持)

3. 华中农业大学校自主科技创新基金,稻瘟菌表观遗传和蛋白修饰调控机制,课题编号:2021ZKPY007,项目年限:2021/5-2024/4(主持)

4. 国家自然科学基金面上项目,O-GlcNAc糖基化修饰调控稻瘟菌致病过程的分子机制研究. 课题编号:32072365, 项目年限:2021/1-2024/12(主持)

5. 国家自然科学基金面上项目,SUMO化修饰调控稻瘟菌MAPK信号途径的分子机制研究,课题编号:31871909,项目年限:2019/1-2022/12(主持)

6. 国家自然科学基金青年项目,GPI锚定修饰在稻瘟菌致病过程中的作用和机理研究,课题编号:31601585,项目年限:2017/1-2019/12(主持)

7. 国家自然科学基金面上项目,稻瘟菌酸性pH信号途径的鉴定及其在致病过程中的作用研究,课题编号:31571952,项目年限:2016/1-2019/12(主持)

8. 华中农业大学校自主科技创新基金,稻瘟菌两种糖基化修饰系统的比较研究,课题编号:0900206306,项目年限:2015/1-2017/12(主持)

 

教学研究与教学改革

华中农业大学实践创新课程提升计划“双百案例”课程,水稻病害研究案例,2022,主持

华中农业大学全英文课程,分子植物病理学,2021,主持

华中农业大学植科院教改项目,新形势下本科“分子植物病理学”课程改革与创新,2019,主持

华中农业大学精品实践课程建设,普通植物病理学实验精品课程,2016,参加

教改论文:陈小林*,董五辈,郑露,杨龙,现代农业背景下植物病理专业“分子植物病理学”课程改革与创新. 教育教学论坛. 2020. 39: 193-194.

 

发明专利及获得奖励

主要奖励:

1. 2017年华中农业大学教学质量优秀二等奖

2. 2015年植物科学技术学院教学质量优秀奖

3. 华中农业大学学士学位论文创新奖指导教师(2019)

4. 华中农业大学优秀本科毕业论文指导教师(2020)

5. 华中农业大学本科生SRF项目指导教师(2017,2018,2019,2021)

6. 华中农业大学本科生省创项目指导教师(2021)

7. 华中农业大学本科生科技创新专项指导教师(2017)

8. 指导研究生获得华中农业大学优秀博士毕业论文(2022)

9. 指导研究生获得华中农业大学优秀硕士毕业论文(2018,2019)

10. 指导研究生获得国家奖学金(2019,2020,2021)

11. 指导研究生获得华中农业大学科研创新奖(2018)

12. 指导研究生获得农业微生物学国家重点实验室年度优秀研究生(2021,2022)

 

学术论文与著作(*表示通讯作者,#表示共同作者):

第一或通讯作者文章

1. Chen, D., Cai, X., Xing, J., Chen, S., Zhao, J., Qu, Z., Li, G., Liu, H., Zheng, L., Huang, J., Chen, X.L.* 2023. A lipid droplet associated protein Nem1 regulates appressorium function for infection of Magnaporthe oryzae. aBIOTECH. doi: 10.1007/s42994-023-00098-5.

2. Chen, D., Kamran, M., Chen, S., Xing, J., Qu, Z., Liu, C., Ren, Z., Cai, X, Chen, X.L.*, Xu, J.* 2023. Two nucleotide sugar transporters are important for cell wall integrity and full virulence of Magnaporthe oryzae. Molecular Plant Pathology, doi: 10.1111/mpp.13304.

3. Wang, W.#*, Cai, X.#, Chen X.L.* 2022. Recent Progress of Deubiquitinating Enzymes in Human and Plant Pathogenic Fungi. Biomolecules, 12(10), 1424.

Nie, Y., Li, G., Li, J., Zhou, X., Zhang, Y., Shi, Q., Zhou, X.*, Li, H.*, Chen X.L.*, Li,Y.* 2022. A novel elicitor MoVcpo is necessary for the virulence of Magnaporthe oryzae and triggers rice defense responses. Frontiers in Plant Science, 13, 1018616.

4. Tang, B., Zhang, Z., Zhao, X., Xu, Y., Wang, L., Chen X.L.*, Wang, W.* 2022. Multi-omics analysis reveals a regulatory network of ZmCCT during maize resistance to gibberella stalk rot at the early stage. Frontiers in Plant Science, 13:917493.

5. Liu C.Y., Liu T., Lv ZW, Qin M.Y., Qu Z.G., Zhang Z.W., Li F.Y., Chen D., Zhang X.R., Chen X.L.*, Shen M.* 2022. A calcineurin regulator MoRCN1 is important for asexual development, stress response and plant infection of Magnaporthe oryzae. Frontiers in Plant Science, 13:925645.

6. Ren, Z.#, Tang, B.#, Xing, J., Liu, C., Cai, X., Hendy, A., Kamran, M., Liu, H., Zheng, L., Huang, J., Chen, X.L.* 2022. MTA1-mediated RNA m6 A modification regulates autophagy and is required for infection of the rice blast fungus. New Phytologist, 235(1):247-262.

7. Cai, X., Xiang, S., He, W., Tang, M., Zhang, S., Chen, D., Zhang, X., Liu, C., Li, G., Xing, J., Li, Y.*, Chen, X.L.*, & Nie, Y.* 2022. Deubiquitinase Ubp3 regulates ribophagy and deubiquitinates Smo1 for appressorium-mediated infection by Magnaporthe oryzae. Molecular Plant Pathology, 23(6):832-844.

8. Chen, D.#, Hu, H.#, He, W., Zhang, S., Tang, M., Xiang, S., Liu, C., Cai, X., Hendy, A., Kamran, M, Liu, H., Zheng, L., Huang, J., Chen, X.L.*, Xing J.* 2021. Endocytic protein Pal1 regulates appressorium formation and is required for full virulence of Magnaporthe oryzae. Molecular Plant Pathology, 23(1):133-147.

9. Tang, B., Liu, C., Li, Z., Zhang, X., Zhou, S., Wang, G.L., Chen, X.L.*, Liu, W.D.* 2021. Multilayer regulatory landscape during pattern-triggered immunity in rice. Plant Biotechnology Journal, 19(12):2629-2645.

10. Liu W.D.*, Triplett L.*, Chen X.L.* 2021. Emerging roles of posttranslational modifications in plant-pathogenic fungi and bacteria. Annual Review of Phytopathology, 2021(59). 59:99-124.

11. Liu C.Y., Talbot N.J.*, Chen X.L.* 2021. Protein glycosylation during infection by plant pathogenic fungi. New Phytologist. 230(4):1329-1335.

12. Zhang X.R.#, Zhang Z.H.#, Chen X.L.* 2021. The redox proteome of thiol proteins in the rice blast fungus Magnaporthe oryzae. Frontiers in Microbiology. 12:648894.

13. Zhang X.R., Chen X.L.* 2021. The emerging roles of ubiquitin-like protein Urm1 in eukaryotes. Cellular Signalling. 81 (2021):109946.

14. Li X.H., Zhao H.J., Chen X.L.* 2021. Screening of marine bioactive antimicrobial compounds for plant pathogens. Marine Drugs. 2021, 19:69.

15. Chen X.L., Liu C.Y., Tang B.Z., Ren Z.Y., Wang G.L. and Liu W.D.* 2020. Quantitative proteomics analysis reveals important roles of N-glycosylation on ER quality control system for development and pathogenesis in Magnaporthe oryzae. PLOS Pathogens, 16(2):e1008355.

16. Cai X., Yan J., Liu C., Xing J., Ren Z., Hendy A., Zheng L., Huang J., Chen X.L.* 2020. Perilipin LDP1 coordinates lipid droplets formation and utilization for appressorium-mediated infection in Magnaporthe oryzae. Environmental Microbiology, 22(7):2843-2857.

17. Liu C.Y., Xing J.J., Cai X., Hendy A., He W.H., Yang J., Huang J.B., Peng Y.L., Ryder L., Chen X.L.* 2020. GPI7-mediated glycosylphosphatidylinositol (GPI) anchoring regulates appressorial penetration and immune evasion during infection of Magnaporthe oryzae. Environmental Microbiology, 22(7):2581-2595.

18. Cai X.#, Wang Z.#, Hou Y.X., Liu C., Hendy A., Xing J., Chen X.L.* 2020. Systematic characterization of the ubiquitin-specific proteases in Magnaporthe oryzae. Phytopathology Research, 8 (2020).

19. Li S.J.#, Song Z.Y.#, Liu C.Y., Chen X.L.*, Han H.Y.* 2019. Biomimetic mineralization-based CRISPR/Cas9 ribonucleoprotein nanoparticles for gene editing. ACS Applied Materials & Interfaces. 11(51):47762-47770.

20. Wang L.Y.#, Cai X.#, Xing J.J., Liu C.Y., Hendy A., Chen X.L.* 2019. URM1-mediated ubiquitin-like modification is required for oxidative stress adaptation during infection of the rice blast fungus. Frontiers in Microbiology, 10:2039.

21. Chen F.F., Ma R.J., Chen X.L.* 2019. Advances of metabolomics in fungal pathogen–plant interactions. Metabolites, 2019(9):169.

22. Hendy A., Xing J.J., Chen X.Y., Chen X.L.* 2019. The farnesyltransferase β-subunit RAM1 regulates localization of RAS proteins and appressorium-mediated infection in Magnaporthe oryzae. Molecular Plant Pathology, 20(9):1264-1278.

23. Liu C.Y.#, Li Z.G.#, Xing J.J., Yang J., Wang Z., Zhang H., Chen D., Peng Y.L., Chen X.L.* 2018. Global analysis of sumoylation function reveals novel insights into development and appressorium-mediated infection of the rice blast fungus. New Phytologist. 219:1031-1047.

24. Chen X.L., Xie X., Liu C.Y., Zeng L.R., Zhou X.P., Luo F., Wang G.L.*, Liu W.D.* 2018. Proteomic analysis of ubiquitinated proteins in rice (Oryza sativa) after treatment with PAMP elicitors. Frontiers in Plant Science, (2018)9:707.

25. Wang Z., Zhang H., Liu C.Y., Xing J.J., Chen X.L.* 2018. A deubiquitinating enzyme Ubp14 is required for development, stress response, nutrient utilization, and pathogenesis of Magnaporthe oryzae. Frontiers in Microbiology, (2018)9:769.

26. Yuan J.L., Wang Z., Xing J.J., Yang Q.Y., Chen X.L.* 2018. Genome-wide Identification and characterization of circular RNAs in the rice blast fungus Magnaporthe oryzae. Scientific Reports, (2018)8:6757.

27. Chen X.L.* 2018. Infection process observation of Magnaporthe oryzae on barley leaves. Bio-protocol, Vol 8, Iss 08. doi: 10.21769/BioProtoc.2833.

28. Li L.W.#, Chen X.L.#, Zhang S.P., Yang J., Chen D., Liu M.X., Zhang H.F., Zheng X.B., Wang P., Peng Y.L.*, Zhang Z.G.* 2017. MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae. PLoS Genetics, 13(5):e1006814.

29. Chen X.L.#*, Shen M.#, Yang J., Xing Y.F., Chen D., Li Z.G., Zhao W.S., Zhang Y. 2017. Peroxisomal fission is induced during appressorium formation and is required for full virulence of the rice blast fungus. Molecular Plant Pathology, 18(2):222-237.

30. Chen X.L.*, Wang Z., Liu C.Y. 2016. Roles of peroxisomes in the rice blast fungus. BioMed Res Int, 2016:9343417.

31. Chen X.L., Shi T., Yang J., Chen D., Xu X.W., Xu J.R., Talbot N.J., Peng Y.L* 2014. N-glycosylation of effector proteins by an alpha-1,3-mannosyltransferase is required to evade host innate immunity by the rice blast fungus. The Plant Cell, 26:1360-1376.

32. Chen X.L., Yang J., and Peng Y.L.* 2011. Large-scale insertional mutagenesis in Magnaporthe oryzae by Agrobacterium tumefaciens-mediated transformation. Methods in Molecular Biology, 722:213-224.

教育经历

暂无内容

工作经历

[1] 2015.3-至今
华中农业大学植物科学技术学院
教学科研 

[2] 2011.7-2014.10
中国农业大学
博士后 

研究方向

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